Annotations: 2CFA

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Thy1	e2cfaA1	A: a+b two layers	X: Thymidylate synthase-complementing protein Thy1 (From Topology)	H: Thymidylate synthase-complementing protein Thy1 (From Topology)	T: Thymidylate synthase-complementing protein Thy1	F: Thy1	ECOD (1.6)
B	Thy1	e2cfaB1	A: a+b two layers	X: Thymidylate synthase-complementing protein Thy1 (From Topology)	H: Thymidylate synthase-complementing protein Thy1 (From Topology)	T: Thymidylate synthase-complementing protein Thy1	F: Thy1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.1360.170	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
A	1.20.5.3070	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B	3.30.1360.170	Alpha Beta	2-Layer Sandwich	Gyrase A	domain 2	CATH (4.3.0)
B	1.20.5.3070	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02511	Thymidylate synthase complementing protein (Thy1)	Thymidylate synthase complementing protein	-	Family
B	PF02511	Thymidylate synthase complementing protein (Thy1)	Thymidylate synthase complementing protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	THYMIDYLATE SYNTHASE	thymidylate synthase (FAD) activity transferase activity, transferring one-carbon groups transferase activity methyltransferase activity 5,10-methylenetetrahydrofolate-dependent methyltransferase activity catalytic activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding thymidylate synthase (FAD) activity transferase activity, transferring one-carbon groups transferase activity methyltransferase activity 5,10-methylenetetrahydrofolate-dependent methyltransferase activity catalytic activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding	methylation metabolic process pyrimidine deoxyribonucleotide metabolic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process pyrimidine nucleotide metabolic process nucleobase-containing compound metabolic process deoxyribonucleotide biosynthetic process pyrimidine deoxyribonucleotide biosynthetic process dTMP metabolic process phosphate-containing compound metabolic process organic substance biosynthetic process dTMP biosynthetic process methylation metabolic process pyrimidine deoxyribonucleotide metabolic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process pyrimidine nucleotide metabolic process nucleobase-containing compound metabolic process deoxyribonucleotide biosynthetic process pyrimidine deoxyribonucleotide biosynthetic process dTMP metabolic process phosphate-containing compound metabolic process organic substance biosynthetic process dTMP biosynthetic process small molecule metabolic process phosphorus metabolic process nucleoside phosphate metabolic process pyrimidine-containing compound metabolic process cellular metabolic process 2'-deoxyribonucleotide biosynthetic process primary metabolic process nucleotide metabolic process deoxyribonucleoside monophosphate metabolic process organic cyclic compound metabolic process biosynthetic process organophosphate biosynthetic process organic cyclic compound biosynthetic process nucleoside phosphate biosynthetic process pyrimidine nucleoside monophosphate biosynthetic process deoxyribose phosphate biosynthetic process pyrimidine deoxyribonucleoside monophosphate metabolic process organic substance metabolic process deoxyribonucleotide metabolic process nucleobase-containing small molecule metabolic process deoxyribonucleoside monophosphate biosynthetic process pyrimidine deoxyribonucleoside monophosphate biosynthetic process pyrimidine-containing compound biosynthetic process nucleoside monophosphate metabolic process carbohydrate derivative biosynthetic process pyrimidine nucleoside monophosphate metabolic process organonitrogen compound metabolic process 2'-deoxyribonucleotide metabolic process deoxyribose phosphate metabolic process nucleobase-containing compound biosynthetic process nucleoside monophosphate biosynthetic process organophosphate metabolic process cellular process pyrimidine nucleotide biosynthetic process pyrimidine deoxyribonucleoside triphosphate biosynthetic process dTTP biosynthetic process pyrimidine deoxyribonucleoside triphosphate metabolic process pyrimidine nucleoside triphosphate biosynthetic process pyrimidine nucleoside triphosphate metabolic process dTTP metabolic process nucleoside triphosphate biosynthetic process nucleoside triphosphate metabolic process	-
B	THYMIDYLATE SYNTHASE	thymidylate synthase (FAD) activity transferase activity, transferring one-carbon groups transferase activity methyltransferase activity 5,10-methylenetetrahydrofolate-dependent methyltransferase activity catalytic activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding thymidylate synthase (FAD) activity transferase activity, transferring one-carbon groups transferase activity methyltransferase activity 5,10-methylenetetrahydrofolate-dependent methyltransferase activity catalytic activity flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding	methylation metabolic process pyrimidine deoxyribonucleotide metabolic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process pyrimidine nucleotide metabolic process nucleobase-containing compound metabolic process deoxyribonucleotide biosynthetic process pyrimidine deoxyribonucleotide biosynthetic process dTMP metabolic process phosphate-containing compound metabolic process organic substance biosynthetic process dTMP biosynthetic process methylation metabolic process pyrimidine deoxyribonucleotide metabolic process nucleotide biosynthetic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process pyrimidine nucleotide metabolic process nucleobase-containing compound metabolic process deoxyribonucleotide biosynthetic process pyrimidine deoxyribonucleotide biosynthetic process dTMP metabolic process phosphate-containing compound metabolic process organic substance biosynthetic process dTMP biosynthetic process small molecule metabolic process phosphorus metabolic process nucleoside phosphate metabolic process pyrimidine-containing compound metabolic process cellular metabolic process 2'-deoxyribonucleotide biosynthetic process primary metabolic process nucleotide metabolic process deoxyribonucleoside monophosphate metabolic process organic cyclic compound metabolic process biosynthetic process organophosphate biosynthetic process organic cyclic compound biosynthetic process nucleoside phosphate biosynthetic process pyrimidine nucleoside monophosphate biosynthetic process deoxyribose phosphate biosynthetic process pyrimidine deoxyribonucleoside monophosphate metabolic process organic substance metabolic process deoxyribonucleotide metabolic process nucleobase-containing small molecule metabolic process deoxyribonucleoside monophosphate biosynthetic process pyrimidine deoxyribonucleoside monophosphate biosynthetic process pyrimidine-containing compound biosynthetic process nucleoside monophosphate metabolic process carbohydrate derivative biosynthetic process pyrimidine nucleoside monophosphate metabolic process organonitrogen compound metabolic process 2'-deoxyribonucleotide metabolic process deoxyribose phosphate metabolic process nucleobase-containing compound biosynthetic process nucleoside monophosphate biosynthetic process organophosphate metabolic process cellular process pyrimidine nucleotide biosynthetic process pyrimidine deoxyribonucleoside triphosphate biosynthetic process dTTP biosynthetic process pyrimidine deoxyribonucleoside triphosphate metabolic process pyrimidine nucleoside triphosphate biosynthetic process pyrimidine nucleoside triphosphate metabolic process dTTP metabolic process nucleoside triphosphate biosynthetic process nucleoside triphosphate metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003669	Thymidylate synthase ThyX	Family
A	IPR036098	Thymidylate synthase ThyX superfamily	Homologous Superfamily
B	IPR003669	Thymidylate synthase ThyX	Family
B	IPR036098	Thymidylate synthase ThyX superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.