Annotations: 2B4H

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	VP4 membrane interaction domain	8039563	3002014	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	VP4 membrane interaction domain	8039563	3002014	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Rota_VP4_MID	e2b4hB2	A: beta sandwiches	X: VP4 membrane interaction domain (From Topology)	H: VP4 membrane interaction domain (From Topology)	T: VP4 membrane interaction domain	F: Rota_VP4_MID	ECOD (1.6)
A	Rota_VP4_MID	e2b4hA1	A: beta sandwiches	X: VP4 membrane interaction domain (From Topology)	H: VP4 membrane interaction domain (From Topology)	T: VP4 membrane interaction domain	F: Rota_VP4_MID	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF17477	Rotavirus VP4 membrane interaction domain (Rota_VP4_MID)	Rotavirus VP4 membrane interaction domain	This entry represents the VP4 membrane interaction domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Outer capsid protein VP4	-	symbiont-mediated disruption of host anatomical structure symbiont entry into host cell via permeabilization of inner membrane biological process involved in interspecies interaction between organisms symbiont entry into host cell via permeabilization of host membrane viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host membrane symbiont-mediated disruption of host cellular anatomical entity symbiont entry into host cell viral process symbiont entry into host disruption of anatomical structure in another organism virion attachment to host cell symbiont-mediated disruption of host anatomical structure symbiont entry into host cell via permeabilization of inner membrane biological process involved in interspecies interaction between organisms symbiont entry into host cell via permeabilization of host membrane viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated perturbation of host membrane symbiont-mediated disruption of host cellular anatomical entity symbiont entry into host cell viral process symbiont entry into host disruption of anatomical structure in another organism virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host permeabilization of host organelle membrane involved in viral entry into host cell	host cellular component host intracellular part host cytoskeleton host cell part host intracellular region cellular anatomical entity host intracellular organelle membrane host intracellular membrane-bounded organelle host cell endoplasmic reticulum-Golgi intermediate compartment host cell cytoplasm host cell cytoplasm part host cell plasma membrane host cell membrane host cellular component host intracellular part host cytoskeleton host cell part host intracellular region cellular anatomical entity host intracellular organelle membrane host intracellular membrane-bounded organelle host cell endoplasmic reticulum-Golgi intermediate compartment host cell cytoplasm host cell cytoplasm part host cell plasma membrane host cell membrane viral capsid icosahedral viral capsid virion component viral outer capsid host cell endoplasmic reticulum host cell rough endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000416	Haemagglutinin outer capsid protein VP4, concanavalin-like domain	Domain
A, B	IPR035330	Rotavirus VP4, membrane interaction domain	Domain
A, B	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A, B	IPR035329	Rotavirus VP4 helical domain	Domain
A, B	IPR042546	Outer capsid protein VP4	Family
A, B	IPR038017	Rotavirus VP4, membrane interaction domain superfamily	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Bitopic proteins	Viral membrane fusion glycoprotein	Nonenvelope rotavirus fusion protein

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.