2AYE

Crystal structure of the unliganded E2 DNA Binding Domain from HPV6a

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
F	d2ayef_	Alpha and beta proteins (a+b)	Ferredoxin-like	Viral DNA-binding domain	Viral DNA-binding domain	Papillomavirus-1 E2 protein	(Human papillomavirus type 6a ) [TaxId: 37122 ],	SCOPe (2.08)
A	d2ayea_	Alpha and beta proteins (a+b)	Ferredoxin-like	Viral DNA-binding domain	Viral DNA-binding domain	Papillomavirus-1 E2 protein	(Human papillomavirus type 6a ) [TaxId: 37122 ],	SCOPe (2.08)
B	d2ayeb_	Alpha and beta proteins (a+b)	Ferredoxin-like	Viral DNA-binding domain	Viral DNA-binding domain	Papillomavirus-1 E2 protein	(Human papillomavirus type 6a ) [TaxId: 37122 ],	SCOPe (2.08)
C	d2ayec_	Alpha and beta proteins (a+b)	Ferredoxin-like	Viral DNA-binding domain	Viral DNA-binding domain	Papillomavirus-1 E2 protein	(Human papillomavirus type 6a ) [TaxId: 37122 ],	SCOPe (2.08)
D	d2ayed_	Alpha and beta proteins (a+b)	Ferredoxin-like	Viral DNA-binding domain	Viral DNA-binding domain	Papillomavirus-1 E2 protein	(Human papillomavirus type 6a ) [TaxId: 37122 ],	SCOPe (2.08)
E	d2ayee_	Alpha and beta proteins (a+b)	Ferredoxin-like	Viral DNA-binding domain	Viral DNA-binding domain	Papillomavirus-1 E2 protein	(Human papillomavirus type 6a ) [TaxId: 37122 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
F	SCOP2B Superfamily	Viral DNA-binding domain	8040442	3001239	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Viral DNA-binding domain	8040442	3001239	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Viral DNA-binding domain	8040442	3001239	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Viral DNA-binding domain	8040442	3001239	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Viral DNA-binding domain	8040442	3001239	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Viral DNA-binding domain	8040442	3001239	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
F	PF00511	e2ayeF1	A: a+b two layers	X: Alpha-beta plaits	H: Viral DNA-binding domain (From Topology)	T: Viral DNA-binding domain	F: PF00511	ECOD (1.6)
A	PF00511	e2ayeA1	A: a+b two layers	X: Alpha-beta plaits	H: Viral DNA-binding domain (From Topology)	T: Viral DNA-binding domain	F: PF00511	ECOD (1.6)
B	PF00511	e2ayeB1	A: a+b two layers	X: Alpha-beta plaits	H: Viral DNA-binding domain (From Topology)	T: Viral DNA-binding domain	F: PF00511	ECOD (1.6)
C	PF00511	e2ayeC1	A: a+b two layers	X: Alpha-beta plaits	H: Viral DNA-binding domain (From Topology)	T: Viral DNA-binding domain	F: PF00511	ECOD (1.6)
D	PF00511	e2ayeD1	A: a+b two layers	X: Alpha-beta plaits	H: Viral DNA-binding domain (From Topology)	T: Viral DNA-binding domain	F: PF00511	ECOD (1.6)
E	PF00511	e2ayeE1	A: a+b two layers	X: Alpha-beta plaits	H: Viral DNA-binding domain (From Topology)	T: Viral DNA-binding domain	F: PF00511	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
F	3.30.70.330	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	RRM (RNA recognition motif) domain	CATH (4.3.0)
A	3.30.70.330	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	RRM (RNA recognition motif) domain	CATH (4.3.0)
B	3.30.70.330	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	RRM (RNA recognition motif) domain	CATH (4.3.0)
C	3.30.70.330	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	RRM (RNA recognition motif) domain	CATH (4.3.0)
D	3.30.70.330	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	RRM (RNA recognition motif) domain	CATH (4.3.0)
E	3.30.70.330	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	RRM (RNA recognition motif) domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF00511	E2 (early) protein, C terminal (PPV_E2_C)	E2 (early) protein, C terminal	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	Regulatory protein E2	DNA binding binding organic cyclic compound binding nucleic acid binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding small molecule binding transcription regulator activity DNA-binding transcription factor activity	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular biosynthetic process cellular metabolic process viral DNA genome replication viral life cycle nucleobase-containing compound biosynthetic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process cellular biosynthetic process cellular metabolic process viral DNA genome replication viral life cycle nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid biosynthetic process biosynthetic process viral genome replication organic cyclic compound biosynthetic process organic substance biosynthetic process viral process cellular process DNA biosynthetic process regulation of biological process biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process RNA metabolic process gene expression RNA biosynthetic process DNA-templated transcription	host intracellular membrane-bounded organelle host cellular component host intracellular part host cell part host intracellular region cellular anatomical entity host cell nucleus host intracellular organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR033668	Regulatory protein E2	Family
A, B, C, D, E A, B, C, D, E, F	IPR042503	E2 regulatory, transactivation domain, subdomain 1	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR001866	Papillomavirus E2, N-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR036050	E2 regulatory, transactivation domain	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR042504	E2 regulatory, transactivation domain, subdomain 2	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR000427	Papillomavirus E2, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR035975	E2/EBNA1, C-terminal	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.