Annotations: 1Z1G

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
I [auth A]	d1z1ga1	Alpha and beta proteins (a+b)	DNA-binding domain	DNA-binding domain	lambda integrase N-terminal domain	lambda integrase N-terminal domain	(Lambdavirus lambda ) [TaxId: 10710 ],	SCOPe (2.08)
I [auth A]	d1z1ga2	Alpha and beta proteins (a+b)	DNA breaking-rejoining enzymes	DNA breaking-rejoining enzymes	Lambda integrase-like, catalytic core	Integrase (Int)	(Lambdavirus lambda ) [TaxId: 10710 ],	SCOPe (2.08)
J [auth B]	d1z1gb1	Alpha and beta proteins (a+b)	DNA-binding domain	DNA-binding domain	lambda integrase N-terminal domain	lambda integrase N-terminal domain	(Lambdavirus lambda ) [TaxId: 10710 ],	SCOPe (2.08)
J [auth B]	d1z1gb2	Alpha and beta proteins (a+b)	DNA breaking-rejoining enzymes	DNA breaking-rejoining enzymes	Lambda integrase-like, catalytic core	Integrase (Int)	(Lambdavirus lambda ) [TaxId: 10710 ],	SCOPe (2.08)
K [auth C]	d1z1gc1	Alpha and beta proteins (a+b)	DNA-binding domain	DNA-binding domain	lambda integrase N-terminal domain	lambda integrase N-terminal domain	(Lambdavirus lambda ) [TaxId: 10710 ],	SCOPe (2.08)
K [auth C]	d1z1gc2	Alpha and beta proteins (a+b)	DNA breaking-rejoining enzymes	DNA breaking-rejoining enzymes	Lambda integrase-like, catalytic core	Integrase (Int)	(Lambdavirus lambda ) [TaxId: 10710 ],	SCOPe (2.08)
L [auth D]	d1z1gd1	Alpha and beta proteins (a+b)	DNA-binding domain	DNA-binding domain	lambda integrase N-terminal domain	lambda integrase N-terminal domain	(Lambdavirus lambda ) [TaxId: 10710 ],	SCOPe (2.08)
L [auth D]	d1z1gd2	Alpha and beta proteins (a+b)	DNA breaking-rejoining enzymes	DNA breaking-rejoining enzymes	Lambda integrase-like, catalytic core	Integrase (Int)	(Lambdavirus lambda ) [TaxId: 10710 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
I [auth A]	SCOP2B Superfamily	lambda integrase clamp domain-like	8091468	3000550	SCOP2B (2022-06-29)
I [auth A]	SCOP2B Superfamily	DNA breaking-rejoining enzymes	8036952	3001127	SCOP2B (2022-06-29)
I [auth A]	SCOP2B Superfamily	DNA-binding domain	8035081	3000183	SCOP2B (2022-06-29)
J [auth B]	SCOP2B Superfamily	DNA-binding domain	8035081	3000183	SCOP2B (2022-06-29)
J [auth B]	SCOP2B Superfamily	DNA breaking-rejoining enzymes	8036952	3001127	SCOP2B (2022-06-29)
J [auth B]	SCOP2B Superfamily	lambda integrase clamp domain-like	8091468	3000550	SCOP2B (2022-06-29)
K [auth C]	SCOP2B Superfamily	DNA breaking-rejoining enzymes	8036952	3001127	SCOP2B (2022-06-29)
K [auth C]	SCOP2B Superfamily	DNA-binding domain	8035081	3000183	SCOP2B (2022-06-29)
K [auth C]	SCOP2B Superfamily	lambda integrase clamp domain-like	8091468	3000550	SCOP2B (2022-06-29)
L [auth D]	SCOP2B Superfamily	DNA breaking-rejoining enzymes	8036952	3001127	SCOP2B (2022-06-29)
L [auth D]	SCOP2B Superfamily	DNA-binding domain	8035081	3000183	SCOP2B (2022-06-29)
L [auth D]	SCOP2B Superfamily	lambda integrase clamp domain-like	8091468	3000550	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
I [auth A]	Phage_integrase_C	e1z1gA7	A: alpha arrays	X: HTH	H: HTH	T: DNA breaking-rejoining enzymes	F: Phage_integrase_C	ECOD (1.6)
I [auth A]	Phage_integrase_N_1	e1z1gA5	A: alpha arrays	X: HTH	H: HTH	T: DNA breaking-rejoining enzymes	F: Phage_integrase_N_1	ECOD (1.6)
I [auth A]	Phage_int_SAM_3	e1z1gA6	A: alpha arrays	X: lambda integrase-N-like	H: lambda integrase-N (From Topology)	T: lambda integrase-N	F: Phage_int_SAM_3	ECOD (1.6)
I [auth A]	Arm-DNA-bind_1	e1z1gA8	A: a+b two layers	X: DNA-binding domain	H: GCC-box binding domain-like (From Topology)	T: GCC-box binding domain-like	F: Arm-DNA-bind_1	ECOD (1.6)
J [auth B]	Phage_integrase_N_1	e1z1gB5	A: alpha arrays	X: HTH	H: HTH	T: DNA breaking-rejoining enzymes	F: Phage_integrase_N_1	ECOD (1.6)
J [auth B]	UNK_F_TYPE	e1z1gB7	A: alpha arrays	X: HTH	H: HTH	T: DNA breaking-rejoining enzymes	F: UNK_F_TYPE	ECOD (1.6)
J [auth B]	Phage_int_SAM_3	e1z1gB6	A: alpha arrays	X: lambda integrase-N-like	H: lambda integrase-N (From Topology)	T: lambda integrase-N	F: Phage_int_SAM_3	ECOD (1.6)
J [auth B]	Arm-DNA-bind_1	e1z1gB8	A: a+b two layers	X: DNA-binding domain	H: GCC-box binding domain-like (From Topology)	T: GCC-box binding domain-like	F: Arm-DNA-bind_1	ECOD (1.6)
K [auth C]	Phage_integrase_C	e1z1gC7	A: alpha arrays	X: HTH	H: HTH	T: DNA breaking-rejoining enzymes	F: Phage_integrase_C	ECOD (1.6)
K [auth C]	Phage_integrase_N_1	e1z1gC5	A: alpha arrays	X: HTH	H: HTH	T: DNA breaking-rejoining enzymes	F: Phage_integrase_N_1	ECOD (1.6)
K [auth C]	Phage_int_SAM_3	e1z1gC6	A: alpha arrays	X: lambda integrase-N-like	H: lambda integrase-N (From Topology)	T: lambda integrase-N	F: Phage_int_SAM_3	ECOD (1.6)
K [auth C]	Arm-DNA-bind_1	e1z1gC8	A: a+b two layers	X: DNA-binding domain	H: GCC-box binding domain-like (From Topology)	T: GCC-box binding domain-like	F: Arm-DNA-bind_1	ECOD (1.6)
L [auth D]	Phage_integrase_N_1	e1z1gD5	A: alpha arrays	X: HTH	H: HTH	T: DNA breaking-rejoining enzymes	F: Phage_integrase_N_1	ECOD (1.6)
L [auth D]	UNK_F_TYPE	e1z1gD7	A: alpha arrays	X: HTH	H: HTH	T: DNA breaking-rejoining enzymes	F: UNK_F_TYPE	ECOD (1.6)
L [auth D]	Phage_int_SAM_3	e1z1gD6	A: alpha arrays	X: lambda integrase-N-like	H: lambda integrase-N (From Topology)	T: lambda integrase-N	F: Phage_int_SAM_3	ECOD (1.6)
L [auth D]	Arm-DNA-bind_1	e1z1gD8	A: a+b two layers	X: DNA-binding domain	H: GCC-box binding domain-like (From Topology)	T: GCC-box binding domain-like	F: Arm-DNA-bind_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
I [auth A], J [auth B], K [auth C], L [auth D]	PF09003	Bacteriophage lambda integrase, Arm DNA-binding domain (Arm-DNA-bind_1)	Bacteriophage lambda integrase, Arm DNA-binding domain	The amino terminal domain of bacteriophage lambda integrase folds into a three-stranded, antiparallel beta-sheet that packs against a C-terminal alpha-helix, adopting a fold that is structurally related to the three-stranded beta-sheet family of DNA- ...	The amino terminal domain of bacteriophage lambda integrase folds into a three-stranded, antiparallel beta-sheet that packs against a C-terminal alpha-helix, adopting a fold that is structurally related to the three-stranded beta-sheet family of DNA-binding domains (which includes the GCC-box DNA-binding domain and the N-terminal domain of Tn916 integrase). This domain is responsible for high-affinity binding to each of the five DNA arm-type sites and is also a context-sensitive modulator of DNA cleavage [1].	Domain
I [auth A], J [auth B], K [auth C], L [auth D]	PF00589	Phage integrase family (Phage_integrase)	Phage integrase family	-	Family
I [auth A], J [auth B], K [auth C], L [auth D]	PF02899	Phage integrase, N-terminal SAM-like domain (Phage_int_SAM_1)	Phage integrase, N-terminal SAM-like domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth I]	29-MER	-	-	-
B [auth J]	29-MER	-	-	-
C [auth K]	29-MER	-	-	-
D [auth L]	29-MER	-	-	-
E, G	5'-D(APCPAPGPGPTPCPAPCPTPAPTPCPAPGPTPCPAPAPAPAPTPAPCP*C)-3'	-	-	-
F, H	25-MER	-	-	-
I [auth A], J [auth B], K [auth C], L [auth D]	Integrase	DNA binding binding organic cyclic compound binding nucleic acid binding hydrolase activity catalytic activity transferase activity integrase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid	establishment of integrated proviral latency viral latency viral process establishment of viral latency biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process establishment of integrated proviral latency viral latency viral process establishment of viral latency biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process DNA integration nucleic acid metabolic process viral genome integration into host DNA DNA recombination provirus excision latent virus replication release from viral latency	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
I [auth A], J [auth B], K [auth C], L [auth D]	IPR011010	DNA breaking-rejoining enzyme, catalytic core	Homologous Superfamily
I [auth A], J [auth B], K [auth C], L [auth D]	IPR010998	Integrase/recombinase, N-terminal	Homologous Superfamily
I [auth A], J [auth B], K [auth C], L [auth D]	IPR015094	Integrase, lambda-type, N-terminal DNA-binding	Domain
I [auth A], J [auth B], K [auth C], L [auth D]	IPR044068	Core-binding (CB) domain	Domain
I [auth A], J [auth B], K [auth C], L [auth D]	IPR002104	Integrase, catalytic domain	Domain
I [auth A], J [auth B], K [auth C], L [auth D]	IPR004107	Integrase, SAM-like, N-terminal	Domain
I [auth A], J [auth B], K [auth C], L [auth D]	IPR013762	Integrase-like, catalytic domain superfamily	Homologous Superfamily
I [auth A], J [auth B], K [auth C], L [auth D]	IPR016177	DNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.