1Z1D
Structural Model for the interaction between RPA32 C-terminal domain and SV40 T antigen origin binding domain.
External Resource: Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d1z1da_ | All alpha proteins | DNA/RNA-binding 3-helical bundle | 'Winged helix' DNA-binding domain | C-terminal domain of RPA32 | C-terminal domain of RPA32 | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
B | d1z1db2 | Alpha and beta proteins (a+b) | Origin of replication-binding domain, RBD-like | Origin of replication-binding domain, RBD-like | The origin DNA-binding domain of SV40 T-antigen | automated matches | (Betapolyomavirus macacae ) [TaxId: 1891767 ], | SCOPe (2.08) |
B | d1z1db3 | Artifacts | Tags | Tags | Tags | N-terminal Tags | (Betapolyomavirus macacae ) [TaxId: 1891767 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF08784 | e1z1dA1 | A: alpha arrays | X: HTH | H: HTH | T: winged | F: PF08784 | ECOD (1.6) |
B | PF02217 | e1z1dB1 | A: a+b two layers | X: Alpha-beta plaits | H: Origin of replication-binding domains | T: Origin of replication-binding domains | F: PF02217 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 1.10.10.10 | Mainly Alpha | Orthogonal Bundle | Arc Repressor Mutant, subunit A | Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | CATH (4.3.0) |
B | 3.40.1310.20 | Alpha Beta | 3-Layer(aba) Sandwich | Replication Protein E1 | Chain: A, | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF08784 | Replication protein A C terminal (RPA_C) | Replication protein A C terminal | This domain corresponds to the C terminal of the single stranded DNA binding protein RPA (replication protein A). RPA is involved in many DNA metabolic pathways including DNA replication, DNA repair, recombination, cell cycle and DNA damage checkpoi ... | Domain | |
PF02217 | Origin of replication binding protein (T_Ag_DNA_bind) | Origin of replication binding protein | This domain of large T antigen binds to the SV40 origin of DNA replication [1]. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR014892 | Replication protein A, C-terminal | Domain | |
IPR040260 | Replication factor A protein-like | Family | |
IPR036388 | Winged helix-like DNA-binding domain superfamily | Homologous Superfamily | |
IPR036390 | Winged helix DNA-binding domain superfamily | Homologous Superfamily | |
IPR014646 | Replication factor A protein 2 | Family | |
IPR012340 | Nucleic acid-binding, OB-fold | Homologous Superfamily | |
IPR001623 | DnaJ domain | Domain | |
IPR027417 | P-loop containing nucleoside triphosphate hydrolase | Homologous Superfamily | |
IPR017910 | Zinc finger, large T-antigen D1-type | Domain | |
IPR003133 | T antigen, Ori-binding | Domain | |
IPR037102 | Zinc finger, large T-antigen D1 domain superfamily | Homologous Superfamily | |
IPR036869 | Chaperone J-domain superfamily | Homologous Superfamily | |
IPR014015 | Helicase, superfamily 3, DNA virus | Domain | |
IPR016392 | Large T antigen, polyomaviridae | Family | |
IPR010932 | Large T antigen, polyomavirus, C-terminal | Domain |
Pharos: Disease Associations Pharos Homepage Annotation
Chains | Drug Target   | Associated Disease |
---|---|---|
P15927 | :