1Z19

Crystal structure of a lambda integrase(75-356) dimer bound to a COC' core site

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
D [auth A]	d1z19a_	Alpha and beta proteins (a+b)	DNA breaking-rejoining enzymes	DNA breaking-rejoining enzymes	Lambda integrase-like, catalytic core	Integrase (Int)	(Lambdavirus lambda ) [TaxId: 10710 ],	SCOPe (2.08)
E [auth B]	d1z19b_	Alpha and beta proteins (a+b)	DNA breaking-rejoining enzymes	DNA breaking-rejoining enzymes	Lambda integrase-like, catalytic core	Integrase (Int)	(Lambdavirus lambda ) [TaxId: 10710 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D [auth A]	SCOP2B Superfamily	DNA breaking-rejoining enzymes	8036952	3001127	SCOP2B (2022-06-29)
D [auth A]	SCOP2B Superfamily	lambda integrase clamp domain-like	8091468	3000550	SCOP2B (2022-06-29)
E [auth B]	SCOP2B Superfamily	lambda integrase clamp domain-like	8091468	3000550	SCOP2B (2022-06-29)
E [auth B]	SCOP2B Superfamily	DNA breaking-rejoining enzymes	8036952	3001127	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D [auth A]	PF00589	e1z19A3	A: alpha arrays	X: HTH	H: HTH	T: DNA breaking-rejoining enzymes	F: PF00589	ECOD (1.6)
D [auth A]	PF02899	e1z19A2	A: alpha arrays	X: lambda integrase-N-like	H: lambda integrase-N (From Topology)	T: lambda integrase-N	F: PF02899	ECOD (1.6)
E [auth B]	PF00589	e1z19B3	A: alpha arrays	X: HTH	H: HTH	T: DNA breaking-rejoining enzymes	F: PF00589	ECOD (1.6)
E [auth B]	PF02899	e1z19B2	A: alpha arrays	X: lambda integrase-N-like	H: lambda integrase-N (From Topology)	T: lambda integrase-N	F: PF02899	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
D [auth A]	1.10.150.130	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
D [auth A]	1.10.443.10	Mainly Alpha	Orthogonal Bundle	hpI Integrase	Chain A	CATH (4.3.0)
E [auth B]	1.10.150.130	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
E [auth B]	1.10.443.10	Mainly Alpha	Orthogonal Bundle	hpI Integrase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
D [auth A], E [auth B]	PF00589	Phage integrase family (Phage_integrase)	Phage integrase family	-	Family
D [auth A], E [auth B]	PF02899	Phage integrase, N-terminal SAM-like domain (Phage_int_SAM_1)	Phage integrase, N-terminal SAM-like domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C]	5'-D(CPTPCPGPTPTPCPAPGPCPTPTPTPTPTPT)-3'	-	-	-
B [auth D]	5'-D(PTPTPTPAPTPAPCPTPAPAPGPTPTPGPGPCPAPTPTPA)-3'	-	-	-
C [auth E]	33-MER	-	-	-
D [auth A], E [auth B]	Integrase	DNA binding binding organic cyclic compound binding nucleic acid binding hydrolase activity catalytic activity transferase activity integrase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid	establishment of integrated proviral latency viral latency viral process establishment of viral latency biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process establishment of integrated proviral latency viral latency viral process establishment of viral latency biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process DNA integration nucleic acid metabolic process viral genome integration into host DNA DNA recombination provirus excision latent virus replication release from viral latency	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
D [auth A], E [auth B]	IPR011010	DNA breaking-rejoining enzyme, catalytic core	Homologous Superfamily
D [auth A], E [auth B]	IPR010998	Integrase/recombinase, N-terminal	Homologous Superfamily
D [auth A], E [auth B]	IPR015094	Integrase, lambda-type, N-terminal DNA-binding	Domain
D [auth A], E [auth B]	IPR044068	Core-binding (CB) domain	Domain
D [auth A], E [auth B]	IPR002104	Integrase, catalytic domain	Domain
D [auth A], E [auth B]	IPR004107	Integrase, SAM-like, N-terminal	Domain
D [auth A], E [auth B]	IPR013762	Integrase-like, catalytic domain superfamily	Homologous Superfamily
D [auth A], E [auth B]	IPR016177	DNA-binding domain superfamily	Homologous Superfamily

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
D [auth A], E [auth B]	MSE	Parent Component: MET
D [auth A], E [auth B]	PTR	Parent Component: TYR RESID: AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.