Annotations: 1YGU

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Y_phosphatase	e1yguA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: Y_phosphatase	ECOD (1.6)
B	Y_phosphatase	e1yguB1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: (Phosphotyrosine protein) phosphatases II	F: Y_phosphatase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.190.10	Alpha Beta	Alpha-Beta Complex	Protein-Tyrosine Phosphatase	Chain A	CATH (4.3.0)
B	3.90.190.10	Alpha Beta	Alpha-Beta Complex	Protein-Tyrosine Phosphatase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00102	Protein-tyrosine phosphatase (Y_phosphatase)	Protein-tyrosine phosphatase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Leukocyte common antigen	phosphoric ester hydrolase activity molecular transducer activity catalytic activity, acting on a protein phosphatase activity signaling receptor activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity transmembrane receptor protein phosphatase activity transmembrane signaling receptor activity transmembrane receptor protein tyrosine phosphatase activity catalytic activity cytoskeletal protein binding phosphoric ester hydrolase activity molecular transducer activity catalytic activity, acting on a protein phosphatase activity signaling receptor activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds protein tyrosine phosphatase activity transmembrane receptor protein phosphatase activity transmembrane signaling receptor activity transmembrane receptor protein tyrosine phosphatase activity catalytic activity cytoskeletal protein binding ankyrin binding protein binding binding heparan sulfate proteoglycan binding proteoglycan binding carbohydrate derivative binding sulfur compound binding spectrin binding protein-containing complex binding signaling receptor binding kinase binding enzyme binding protein kinase binding heparin binding glycosaminoglycan binding	adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains response to stimulus regulation of leukocyte activation regulation of cell activation B cell activation involved in immune response positive regulation of macromolecule biosynthetic process regulation of primary metabolic process multicellular organism development positive regulation of immune response organic substance biosynthetic process regulation of immune system process positive regulation of macromolecule metabolic process system development positive regulation of DNA recombination adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains response to stimulus regulation of leukocyte activation regulation of cell activation B cell activation involved in immune response positive regulation of macromolecule biosynthetic process regulation of primary metabolic process multicellular organism development positive regulation of immune response organic substance biosynthetic process regulation of immune system process positive regulation of macromolecule metabolic process system development positive regulation of DNA recombination positive regulation of immunoglobulin mediated immune response immune response cellular metabolic process DNA recombination primary metabolic process DNA metabolic process immune effector process regulation of gene expression biosynthetic process positive regulation of DNA metabolic process regulation of response to stimulus B cell mediated immunity positive regulation of production of molecular mediator of immune response regulation of macromolecule biosynthetic process metabolic process regulation of DNA metabolic process immunoglobulin production regulation of developmental process positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains somatic cell DNA recombination positive regulation of cellular metabolic process somatic diversification of immunoglobulins involved in immune response positive regulation of lymphocyte activation somatic recombination of immunoglobulin gene segments positive regulation of biosynthetic process regulation of immunoglobulin mediated immune response leukocyte activation involved in immune response regulation of B cell activation positive regulation of isotype switching positive regulation of immune effector process positive regulation of cellular process production of molecular mediator of immune response positive regulation of immunoglobulin production regulation of isotype switching cell activation regulation of macromolecule metabolic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of gene expression immune system process somatic diversification of immune receptors via germline recombination within a single locus cellular process positive regulation of cellular biosynthetic process regulation of lymphocyte activation lymphocyte mediated immunity regulation of immune effector process multicellular organismal process regulation of DNA recombination positive regulation of leukocyte mediated immunity regulation of cellular process cell activation involved in immune response nucleobase-containing compound metabolic process positive regulation of developmental process positive regulation of cell activation positive regulation of metabolic process anatomical structure development positive regulation of leukocyte activation leukocyte mediated immunity somatic diversification of immune receptors regulation of nucleobase-containing compound metabolic process positive regulation of adaptive immune response positive regulation of immune system process somatic recombination of immunoglobulin genes involved in immune response developmental process regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of adaptive immune response regulation of cellular metabolic process regulation of B cell mediated immunity somatic diversification of immunoglobulins organic cyclic compound metabolic process regulation of leukocyte mediated immunity regulation of immune response positive regulation of multicellular organismal process regulation of production of molecular mediator of immune response macromolecule metabolic process regulation of metabolic process isotype switching immune system development immunoglobulin production involved in immunoglobulin-mediated immune response positive regulation of lymphocyte mediated immunity cellular biosynthetic process positive regulation of biological process lymphocyte activation positive regulation of B cell mediated immunity leukocyte activation positive regulation of response to stimulus regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains organic substance metabolic process positive regulation of isotype switching to IgG isotypes regulation of multicellular organismal process lymphocyte activation involved in immune response regulation of biosynthetic process B cell activation biological regulation gene expression adaptive immune response immunoglobulin mediated immune response positive regulation of B cell activation regulation of isotype switching to IgG isotypes regulation of lymphocyte mediated immunity regulation of immunoglobulin production isotype switching to IgG isotypes cellular response to stimulus cell surface receptor signaling pathway via STAT regulation of signaling cell surface receptor signaling pathway signaling regulation of signal transduction cell communication regulation of receptor signaling pathway via JAK-STAT regulation of cell communication signal transduction regulation of receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT thymic T cell selection cellular developmental process hemopoiesis cell development mononuclear cell differentiation lymphocyte differentiation T cell differentiation in thymus T cell activation cell differentiation negative thymic T cell selection T cell differentiation negative T cell selection T cell selection leukocyte differentiation cytokine production regulation of cytokine production interleukin-8 production regulation of interleukin-8 production negative regulation of biological process negative regulation of interleukin-2 production negative regulation of cellular metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process regulation of interleukin-2 production negative regulation of metabolic process interleukin-2 production negative regulation of cytokine production negative regulation of cellular biosynthetic process negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process protein dephosphorylation organonitrogen compound metabolic process dephosphorylation macromolecule modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein tyrosine kinase activity regulation of catalytic activity negative regulation of catalytic activity regulation of transferase activity negative regulation of kinase activity negative regulation of transferase activity regulation of phosphate metabolic process peptidyl-amino acid modification negative regulation of protein modification process negative regulation of protein metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process regulation of molecular function regulation of protein tyrosine kinase activity regulation of kinase activity negative regulation of protein phosphorylation regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process peptidyl-tyrosine modification negative regulation of peptidyl-tyrosine phosphorylation regulation of peptidyl-tyrosine phosphorylation negative regulation of molecular function regulation of protein kinase activity negative regulation of protein kinase activity negative regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation peptidyl-tyrosine phosphorylation cell death extrinsic apoptotic signaling pathway apoptotic signaling pathway apoptotic process programmed cell death negative regulation of signaling negative regulation of intracellular signal transduction intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of response to stimulus regulation of MAPK cascade negative regulation of signal transduction negative regulation of ERK1 and ERK2 cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade negative regulation of MAPK cascade regulation of localization import into cell positive regulation of cellular component organization regulation of cellular component organization transport vesicle-mediated transport cellular component organization localization positive regulation of endocytosis phagocytosis cellular component organization or biogenesis regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of phagocytosis positive regulation of transport endocytosis regulation of stem cell proliferation cell population proliferation positive regulation of cell population proliferation positive regulation of stem cell proliferation stem cell proliferation regulation of cell population proliferation positive regulation of phosphoprotein phosphatase activity regulation of phosphatase activity positive regulation of phosphate metabolic process regulation of protein tyrosine phosphatase activity positive regulation of phosphatase activity positive regulation of protein tyrosine phosphatase activity positive regulation of phosphorus metabolic process positive regulation of dephosphorylation regulation of dephosphorylation regulation of hydrolase activity positive regulation of protein metabolic process regulation of phosphoprotein phosphatase activity positive regulation of molecular function positive regulation of protein modification process regulation of protein dephosphorylation positive regulation of catalytic activity positive regulation of protein dephosphorylation positive regulation of hydrolase activity regulation of cell adhesion negative regulation of cell adhesion cell adhesion negative regulation of cell adhesion involved in substrate-bound cell migration substrate-dependent cell migration cell migration cell motility T cell mediated immunity negative regulation of lymphocyte mediated immunity negative regulation of leukocyte mediated cytotoxicity negative regulation of cell killing regulation of T cell mediated immunity T cell mediated cytotoxicity negative regulation of immune response negative regulation of T cell mediated cytotoxicity negative regulation of immune effector process regulation of leukocyte mediated cytotoxicity negative regulation of adaptive immune response leukocyte mediated cytotoxicity negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of T cell mediated cytotoxicity negative regulation of immune system process regulation of cell killing negative regulation of leukocyte mediated immunity negative regulation of T cell mediated immunity cell killing membrane organization plasma membrane raft localization cellular localization plasma membrane raft distribution localization within membrane membrane raft localization plasma membrane organization membrane raft organization endomembrane system organization membrane raft distribution response to aldosterone response to organic substance response to ketone response to lipid response to endogenous stimulus response to alcohol response to oxygen-containing compound response to mineralocorticoid response to corticosteroid response to hormone response to steroid hormone response to chemical response to organic cyclic compound cell-cell adhesion leukocyte cell-cell adhesion positive regulation of phosphorylation positive regulation of protein phosphorylation positive regulation of kinase activity positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of B cell proliferation leukocyte proliferation regulation of B cell proliferation lymphocyte proliferation positive regulation of mononuclear cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation positive regulation of lymphocyte proliferation B cell proliferation mononuclear cell proliferation positive regulation of leukocyte proliferation regulation of mononuclear cell proliferation heterotypic cell-cell adhesion natural killer cell activation natural killer cell differentiation positive regulation of leukocyte mediated cytotoxicity positive regulation of T cell mediated cytotoxicity positive regulation of T cell mediated immunity positive regulation of cell killing positive regulation of T cell activation positive regulation of T cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte cell-cell adhesion positive regulation of cell-cell adhesion regulation of cell-cell adhesion T cell proliferation positive regulation of cell adhesion regulation of T cell activation regulation of T cell proliferation biological process involved in interspecies interaction between organisms response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus defense response to other organism response to stress response to external biotic stimulus response to virus positive regulation of cell communication immune response-regulating cell surface receptor signaling pathway positive regulation of signal transduction regulation of Fc receptor mediated stimulatory signaling pathway immune response-activating signaling pathway immune response-regulating signaling pathway immune response-activating cell surface receptor signaling pathway Fc receptor mediated stimulatory signaling pathway positive regulation of Fc receptor mediated stimulatory signaling pathway activation of immune response positive regulation of signaling B cell differentiation B cell receptor signaling pathway antigen receptor-mediated signaling pathway regulation of leukocyte differentiation regulation of cell differentiation positive regulation of T cell differentiation regulation of cell development gamma-delta T cell activation positive regulation of cell development regulation of gamma-delta T cell differentiation regulation of T cell differentiation positive regulation of hemopoiesis positive regulation of cell differentiation regulation of lymphocyte differentiation regulation of multicellular organismal development regulation of gamma-delta T cell activation positive regulation of gamma-delta T cell differentiation gamma-delta T cell differentiation regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of gamma-delta T cell activation positive regulation of lymphocyte differentiation T cell receptor signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade positive regulation of intracellular signal transduction cell cycle phase transition cell cycle cell cycle process regulation of macrophage activation regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response myeloid leukocyte activation macrophage activation regulation of response to stress leukocyte activation involved in inflammatory response regulation of neuroinflammatory response regulation of inflammatory response negative regulation of microglial cell activation negative regulation of cell activation negative regulation of response to external stimulus negative regulation of defense response microglial cell activation inflammatory response glial cell activation regulation of microglial cell activation negative regulation of neuroinflammatory response neuroinflammatory response negative regulation of leukocyte activation negative regulation of macrophage activation regulation of alpha-beta T cell activation positive regulation of alpha-beta T cell proliferation alpha-beta T cell proliferation alpha-beta T cell activation positive regulation of alpha-beta T cell activation regulation of alpha-beta T cell proliferation positive thymic T cell selection positive T cell selection hematopoietic stem cell migration positive regulation of locomotion regulation of cell motility positive regulation of cell migration positive regulation of hematopoietic stem cell migration regulation of hematopoietic stem cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration locomotion regulation of humoral immune response humoral immune response regulation of humoral immune response mediated by circulating immunoglobulin humoral immune response mediated by circulating immunoglobulin positive regulation of humoral immune response positive regulation of humoral immune response mediated by circulating immunoglobulin response to cytokine cytokine-mediated signaling pathway cellular response to cytokine stimulus cellular response to organic substance regulation of cytokine-mediated signaling pathway regulation of response to cytokine stimulus cellular response to chemical stimulus negative regulation of response to cytokine stimulus negative regulation of cytokine-mediated signaling pathway protein autophosphorylation regulation of protein autophosphorylation negative regulation of protein autophosphorylation regulation of programmed cell death positive regulation of apoptotic signaling pathway positive regulation of programmed cell death regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway regulation of apoptotic signaling pathway animal organ development hematopoietic or lymphoid organ development tissue development bone marrow development skeletal system development bone development regulation of antigen receptor-mediated signaling pathway positive regulation of antigen receptor-mediated signaling pathway DN2 thymocyte differentiation positive regulation of interleukin-2 production positive regulation of cytokine production inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process monoatomic ion transmembrane transport calcium ion homeostasis negative regulation of sequestering of calcium ion calcium ion transport metal ion transport maintenance of location in cell monoatomic cation transmembrane transport intracellular monoatomic cation homeostasis monoatomic ion homeostasis monoatomic ion transport intracellular chemical homeostasis monoatomic cation homeostasis monoatomic cation transport regulation of sequestering of calcium ion intracellular monoatomic ion homeostasis calcium ion transmembrane import into cytosol sequestering of calcium ion inorganic ion transmembrane transport inorganic cation transmembrane transport maintenance of location transmembrane transport release of sequestered calcium ion into cytosol cellular homeostasis chemical homeostasis calcium ion transmembrane transport response to ionizing radiation response to radiation response to abiotic stimulus response to gamma radiation stem cell development stem cell differentiation regulation of cell cycle hematopoietic progenitor cell differentiation regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production positive regulation of peptidyl-tyrosine phosphorylation	membrane microdomain membrane cellular anatomical entity cell periphery cell surface plasma membrane external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle membrane microdomain membrane cellular anatomical entity cell periphery cell surface plasma membrane external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle anchoring junction cell junction focal adhesion cell-substrate junction membrane raft intracellular anatomical structure intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle secretory granule secretory vesicle cytoplasm organelle membrane secretory granule membrane cell projection bleb plasma membrane bounded cell projection cytoplasmic side of plasma membrane cytoplasmic side of membrane
C, D	Polyoma Middle T antigen	-	-	host cellular component host cell part host cell membrane cellular anatomical entity membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR016130	Protein-tyrosine phosphatase, active site	Active Site
A, B	IPR024739	Protein tyrosine phosphatase, receptor type, N-terminal	Domain
A, B	IPR016335	Receptor-type tyrosine-protein phosphatase C	Family
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR003595	Protein-tyrosine phosphatase, catalytic	Domain
A, B	IPR029021	Protein-tyrosine phosphatase-like	Homologous Superfamily
A, B	IPR003961	Fibronectin type III	Domain
A, B	IPR000242	Tyrosine-specific protein phosphatase, PTPase domain	Domain
A, B	IPR000387	Tyrosine-specific protein phosphatases domain	Domain
A, B	IPR036116	Fibronectin type III superfamily	Homologous Superfamily
C, D	IPR036092	Small/middle T-antigen superfamily	Homologous Superfamily
C, D	IPR001623	DnaJ domain	Domain
C, D	IPR003354	Small/middle T-antigen	Domain
C, D	IPR036869	Chaperone J-domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P08575	rheumatoid arthritis severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive hepatitis C virus infection retinal disease Liver Cirrhosis, Experimental prostate cancer severe combined immunodeficiency ulcerative colitis inflammatory bowel disease juvenile dermatomyositis subependymal giant cell astrocytoma adenoma lung disease vitiligo autoimmune disease rheumatoid arthritis severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, NK cell-positive hepatitis C virus infection retinal disease Liver Cirrhosis, Experimental prostate cancer severe combined immunodeficiency ulcerative colitis inflammatory bowel disease juvenile dermatomyositis subependymal giant cell astrocytoma adenoma lung disease vitiligo autoimmune disease malignant ependymoma breast disease medulloblastoma chronic obstructive pulmonary disease non-small cell lung carcinoma dermatomyositis ovarian cancer digestive system neuroendocrine neoplasm pancreatic intraductal papillary-mucinous neoplasm glioblastoma IgA glomerulonephritis psoriasis interstitial cystitis kidney disease Sjogren syndrome lung cancer systemic lupus erythematosus arthritic joint disease lymphatic system disease bipolar disorder malignant glioma cancer multiple sclerosis Crohn disease diabetes mellitus pancreatic ductal adenocarcinoma pilocytic astrocytoma head and neck cancer inborn carbohydrate metabolic disorder invasive ductal breast carcinoma large cell medulloblastoma skin disease lung carcinoma asthma lymphoplasmacytic lymphoma bone marrow disease chronic kidney disease nephrosclerosis cutaneous lupus erythematosus osteosarcoma digestive system disease pancreatic intraductal papillary-mucinous carcinoma Duchenne muscular dystrophy pituitary cancer

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B	MSE	Parent Component: MET
C, D	PTR	Parent Component: TYR RESID: AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.