Annotations: 1XAK

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1xaka_	All beta proteins	Immunoglobulin-like beta-sandwich	Accessory protein X4 (ORF8, ORF7a)	Accessory protein X4 (ORF8, ORF7a)	Accessory protein X4 (ORF8, ORF7a)	(Severe acute respiratory syndrome-related coronavirus ) [TaxId: 694009 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	SARS coronavirus accessory protein X4 (ORF8 ORF7a)	8055374	4007538	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	SARS coronavirus accessory protein X4 (ORF8 ORF7a)	8055375	3002051	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	SARS_X4	e1xakA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Accessory protein X4 (ORF8, ORF7a) (From Topology)	T: Accessory protein X4 (ORF8, ORF7a)	F: SARS_X4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.1550	Mainly Beta	Sandwich	Immunoglobulin-like	SARS coronavirus X4	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08779	Betacoronavirus NS7A protein (bCoV_NS7A)	Betacoronavirus NS7A protein	This entry corresponds to the Human SARS virus NS7A protein (also known as 7a, accessory protein 7a, X4 and U122). The structure of this protein shows similarities to the immunoglobulin like fold and a known member of the immunoglobulin (Ig) domain s ...	This entry corresponds to the Human SARS virus NS7A protein (also known as 7a, accessory protein 7a, X4 and U122). The structure of this protein shows similarities to the immunoglobulin like fold and a known member of the immunoglobulin (Ig) domain superfamily [9,10], which suggests a binding activity to integrin I domains [1]. In SARS-CoV-infected cells, the NS7A protein is expressed and retained intra-cellularly within the Golgi network [2]. NS7A has been implicated to function during the replication cycle of SARS-CoV [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	SARS ORF7A ACCESSORY PROTEIN	-	symbiont-mediated perturbation of host defense response suppression by virus of host tetherin activity response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to defenses of other organism modulation by virus of host process response to external stimulus virus-mediated perturbation of host defense response biological process involved in interaction with host response to biotic stimulus biological process involved in symbiotic interaction modulation by symbiont of host process viral process symbiont-mediated perturbation of host defense response suppression by virus of host tetherin activity response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to defenses of other organism modulation by virus of host process response to external stimulus virus-mediated perturbation of host defense response biological process involved in interaction with host response to biotic stimulus biological process involved in symbiotic interaction modulation by symbiont of host process viral process response to host response to external biotic stimulus modulation of process of another organism modulation by virus of host cellular process symbiont-mediated perturbation of host cellular process symbiont-mediated suppression of host type I interferon-mediated signaling pathway symbiont-mediated suppression of host signal transduction pathway symbiont-mediated suppression of host interferon-mediated signaling pathway cellular process symbiont-mediated perturbation of host signal transduction pathway symbiont-mediated perturbation of host cell cycle G0/G1 transition checkpoint symbiont-mediated perturbation of host cell cycle progression	virion component virion membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host cell endoplasmic reticulum host intracellular region cellular anatomical entity host cell cytoplasm part host intracellular organelle host cell Golgi apparatus cell periphery virion component virion membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host cell cytoplasm host cell part host cell endoplasmic reticulum host intracellular region cellular anatomical entity host cell cytoplasm part host intracellular organelle host cell Golgi apparatus cell periphery plasma membrane membrane host cell membrane host cell endoplasmic reticulum-Golgi intermediate compartment membrane host cell endoplasmic reticulum-Golgi intermediate compartment host cell endomembrane system host cell endoplasmic reticulum membrane host cell Golgi membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR014888	Structural accessory protein ORF7a, SARS-CoV-like	Family
A	IPR036495	ORF7a superfamily, coronavirus	Homologous Superfamily
A	IPR044871	Structural accessory protein ORF7a, SARS-CoV-like, X4e domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.