1X79

Crystal structure of human GGA1 GAT domain complexed with the GAT-binding domain of Rabaptin5

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d1x79b_	Coiled coil proteins	Parallel coiled-coil	G protein-binding domain	Rabaptin-5	Rabaptin-5	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d1x79c_	Coiled coil proteins	Parallel coiled-coil	G protein-binding domain	Rabaptin-5	Rabaptin-5	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1x79a_	All alpha proteins	Spectrin repeat-like	GAT-like domain	GAT domain	ADP-ribosylation factor binding protein Gga1	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF03127	e1x79A1	A: alpha bundles	X: Spectrin repeat-like	H: GAT-like domain (From Topology)	T: GAT-like domain	F: PF03127	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.20.5.340	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
C	1.20.5.340	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
A	1.20.58.160	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, C	PF09311	Rabaptin-like protein (Rab5-bind)	Rabaptin-like protein	-	Coiled-coil
A	PF03127	GAT domain (GAT)	GAT domain	The GAT domain is responsible for binding of GGA proteins to several members of the ARF family including ARF1 [1] and ARF3. The GAT domain stabilises membrane bound ARF1 in its GTP bound state, by interfering with GAP proteins [2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B, C	Rab GTPase binding effector protein 1	protein binding binding protein domain specific binding identical protein binding protein homodimerization activity protein dimerization activity molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity GTPase regulator activity protein binding binding protein domain specific binding identical protein binding protein homodimerization activity protein dimerization activity molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity growth factor activity receptor ligand activity signaling receptor activator activity GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity nucleoside-triphosphatase regulator activity	membrane organization cellular component organization membrane fusion cellular process cellular component organization or biogenesis Golgi to plasma membrane transport cellular localization post-Golgi vesicle-mediated transport transport localization within membrane establishment of localization vesicle-mediated transport vesicle-mediated transport to the plasma membrane localization membrane organization cellular component organization membrane fusion cellular process cellular component organization or biogenesis Golgi to plasma membrane transport cellular localization post-Golgi vesicle-mediated transport transport localization within membrane establishment of localization vesicle-mediated transport vesicle-mediated transport to the plasma membrane localization Golgi vesicle transport import into cell endocytosis protein localization establishment of protein localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization apoptotic process cell death programmed cell death protein localization to cell periphery protein localization to cilium protein localization to membrane protein localization to ciliary membrane protein localization to organelle	membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle endosome membrane membrane-bounded organelle intracellular anatomical structure early endosome endosome intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle cytoplasm vesicle endosome membrane membrane early endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane recycling endosome endocytic vesicle protein-containing complex
A	ADP-ribosylation factor binding protein GGA1	binding phospholipid binding lipid binding phosphatidylinositol binding small GTPase binding protein binding enzyme binding GTPase binding ubiquitin binding ubiquitin-like protein binding	protein localization Golgi to plasma membrane transport establishment of protein localization cellular localization nitrogen compound transport post-Golgi vesicle-mediated transport transport establishment of protein localization to plasma membrane Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization Golgi to plasma membrane transport establishment of protein localization cellular localization nitrogen compound transport post-Golgi vesicle-mediated transport transport establishment of protein localization to plasma membrane Golgi to plasma membrane protein transport vesicle-mediated transport localization cellular macromolecule localization protein localization to cell periphery establishment of protein localization to membrane protein localization to plasma membrane organic substance transport localization within membrane protein localization to membrane establishment of localization vesicle-mediated transport to the plasma membrane protein transport macromolecule localization cellular process Golgi vesicle transport protein localization to cell surface organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process positive regulation of protein metabolic process positive regulation of biological process regulation of primary metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process regulation of biological process regulation of protein metabolic process biological regulation regulation of macromolecule metabolic process regulation of catabolic process positive regulation of protein catabolic process positive regulation of catabolic process regulation of metabolic process regulation of protein catabolic process intracellular transport establishment of localization in cell intracellular protein transport endosomal transport cytosolic transport retrograde transport, endosome to Golgi protein localization to cilium protein localization to ciliary membrane protein localization to organelle	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex early endosome endosome intracellular vesicle endomembrane system cytoplasmic vesicle vesicle Golgi apparatus subcompartment Golgi apparatus organelle subcompartment trans-Golgi network endosome membrane early endosome membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B, C	IPR003914	Rabaptin	Family
B, C	IPR015390	Rabaptin, GTPase-Rab5 binding domain	Domain
B, C	IPR018514	Rabaptin coiled-coil domain	Domain
A	IPR002014	VHS domain	Domain
A	IPR008942	ENTH/VHS	Homologous Superfamily
A	IPR041198	N-terminal extension of GAT domain	Domain
A	IPR008153	Gamma-adaptin ear (GAE) domain	Domain
A	IPR038425	GAT domain superfamily	Homologous Superfamily
A	IPR013041	Clathrin adaptor, appendage, Ig-like subdomain superfamily	Homologous Superfamily
A	IPR004152	GAT domain	Domain
A	IPR008152	Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain	Domain
A	IPR027422	ADP-ribosylation factor-binding protein GGA1-3	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B, C	Pharos: Q15276	rheumatoid arthritis breast cancer hereditary spastic paraplegia ovarian cancer psoriasis Gaucher disease malignant glioma pancreatic ductal adenocarcinoma glioblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia
A	Pharos: Q9UJY5	astrocytic tumor medulloblastoma ovarian cancer sarcoidosis malignant ependymoma oligodendroglioma primitive neuroectodermal tumor X-linked mixed deafness with perilymphatic gusher Malignant neoplasm of breast osteosarcoma psoriasis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.