1WNC

Crystal structure of the SARS-CoV Spike protein fusion core

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1wnca_	Coiled coil proteins	Stalk segment of viral fusion proteins	Coronavirus S2 glycoprotein	Coronavirus spike glycoprotein S2 fragments	E2 spike glycoprotein	(Severe acute respiratory syndrome-related coronavirus ) [TaxId: 694009 ], (Severe acute respiratory syndrome-related coronavirus ) [TaxId: 694009 ],	SCOPe (2.08)
C	d1wncc_	Coiled coil proteins	Stalk segment of viral fusion proteins	Coronavirus S2 glycoprotein	Coronavirus spike glycoprotein S2 fragments	E2 spike glycoprotein	(Severe acute respiratory syndrome-related coronavirus ) [TaxId: 694009 ], (Severe acute respiratory syndrome-related coronavirus ) [TaxId: 694009 ],	SCOPe (2.08)
D	d1wncd_	Coiled coil proteins	Stalk segment of viral fusion proteins	Coronavirus S2 glycoprotein	Coronavirus spike glycoprotein S2 fragments	E2 spike glycoprotein	(Severe acute respiratory syndrome-related coronavirus ) [TaxId: 694009 ], (Severe acute respiratory syndrome-related coronavirus ) [TaxId: 694009 ],	SCOPe (2.08)
E	d1wnce_	Coiled coil proteins	Stalk segment of viral fusion proteins	Coronavirus S2 glycoprotein	Coronavirus spike glycoprotein S2 fragments	E2 spike glycoprotein	(Severe acute respiratory syndrome-related coronavirus ) [TaxId: 694009 ], (Severe acute respiratory syndrome-related coronavirus ) [TaxId: 694009 ],	SCOPe (2.08)
F	d1wncf_	Coiled coil proteins	Stalk segment of viral fusion proteins	Coronavirus S2 glycoprotein	Coronavirus spike glycoprotein S2 fragments	E2 spike glycoprotein	(Severe acute respiratory syndrome-related coronavirus ) [TaxId: 694009 ], (Severe acute respiratory syndrome-related coronavirus ) [TaxId: 694009 ],	SCOPe (2.08)
B	d1wncb_	Coiled coil proteins	Stalk segment of viral fusion proteins	Coronavirus S2 glycoprotein	Coronavirus spike glycoprotein S2 fragments	E2 spike glycoprotein	(Severe acute respiratory syndrome-related coronavirus ) [TaxId: 694009 ], (Severe acute respiratory syndrome-related coronavirus ) [TaxId: 694009 ],	SCOPe (2.08)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.5.300	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
C	1.20.5.300	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
D	1.20.5.300	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
E	1.20.5.300	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
F	1.20.5.300	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
B	1.20.5.300	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF01601	Coronavirus spike glycoprotein S2 (CoV_S2)	Coronavirus spike glycoprotein S2	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	E2 glycoprotein	host cell surface binding binding host cell surface receptor binding identical protein binding protein binding	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell membrane organization cellular component organization membrane fusion cellular process cellular component organization or biogenesis symbiont-mediated perturbation of host defense response suppression by virus of host tetherin activity response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell membrane organization cellular component organization membrane fusion cellular process cellular component organization or biogenesis symbiont-mediated perturbation of host defense response suppression by virus of host tetherin activity response to host defenses biological process involved in interspecies interaction between organisms response to stimulus response to other organism response to defenses of other organism modulation by virus of host process response to external stimulus virus-mediated perturbation of host defense response biological process involved in interaction with host response to biotic stimulus biological process involved in symbiotic interaction modulation by symbiont of host process response to host response to external biotic stimulus modulation of process of another organism modulation by virus of host cellular process virion attachment to host cell receptor-mediated virion attachment to host cell adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host fusion of virus membrane with host plasma membrane import into cell transport establishment of localization vesicle-mediated transport localization symbiont entry into host cell symbiont entry into host endocytosis involved in viral entry into host cell endocytosis transport of virus symbiont-mediated perturbation of host cellular process symbiont-mediated suppression of host type I interferon-mediated signaling pathway symbiont-mediated suppression of host signal transduction pathway symbiont-mediated suppression of host interferon-mediated signaling pathway symbiont-mediated perturbation of host signal transduction pathway regulation of biological process positive regulation of viral life cycle positive regulation of viral process biological regulation positive regulation of biological process modulation by symbiont of entry into host regulation of viral entry into host cell regulation of viral life cycle regulation of viral process positive regulation of viral entry into host cell positive regulation by symbiont of entry into host regulation of biological process involved in symbiotic interaction	membrane cellular anatomical entity host intracellular membrane-bounded organelle host cellular component host intracellular part host cell membrane host cell cytoplasm part host intracellular organelle host cell endoplasmic reticulum-Golgi intermediate compartment membrane host cell endoplasmic reticulum-Golgi intermediate compartment host cell cytoplasm host cell part host intracellular region host cell plasma membrane membrane cellular anatomical entity host intracellular membrane-bounded organelle host cellular component host intracellular part host cell membrane host cell cytoplasm part host intracellular organelle host cell endoplasmic reticulum-Golgi intermediate compartment membrane host cell endoplasmic reticulum-Golgi intermediate compartment host cell cytoplasm host cell part host intracellular region host cell plasma membrane virion component virion membrane viral membrane viral envelope

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR044873	Spike glycoprotein S2, coronavirus, heptad repeat 1	Domain
A, B, C, D, E A, B, C, D, E, F	IPR018548	Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR044341	Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like	Domain
A, B, C, D, E A, B, C, D, E, F	IPR032500	Spike glycoprotein S1, N-terminal domain, betacoronavirus-like	Domain
A, B, C, D, E A, B, C, D, E, F	IPR042578	Spike glycoprotein, betacoronavirus	Family
A, B, C, D, E A, B, C, D, E, F	IPR036326	Spike S1 subunit, receptor binding domain superfamily, betacoronavirus	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR043002	Spike glycoprotein, N-terminal domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR044874	Spike glycoprotein S2, coronavirus, heptad repeat 2	Domain
A, B, C, D, E A, B, C, D, E, F	IPR043473	Spike glycoprotein S2 superfamily, coronavirus	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR043607	Coronavirus spike glycoprotein S1, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F	IPR002552	Spike glycoprotein S2, coronavirus	Domain
A, B, C, D, E A, B, C, D, E, F	IPR044370	Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.