Annotations: 1TY4

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1ty4a_	Membrane and cell surface proteins and peptides	Toxins' membrane translocation domains	Bcl-2 inhibitors of programmed cell death	Bcl-2 inhibitors of programmed cell death	Apoptosis regulator ced-9	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)
B	d1ty4b_	Membrane and cell surface proteins and peptides	Toxins' membrane translocation domains	Bcl-2 inhibitors of programmed cell death	Bcl-2 inhibitors of programmed cell death	Apoptosis regulator ced-9	(Caenorhabditis elegans ) [TaxId: 6239 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Bcl-2-like inhibitors of programmed cell death	8037483	3001974	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Bcl-2-like inhibitors of programmed cell death	8037483	3001974	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00452,PF02180	e1ty4A1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: PF00452,PF02180	ECOD (1.6)
B	PF00452,PF02180	e1ty4B1	A: alpha arrays	X: Toxins' membrane translocation domains	H: Bcl-2 inhibitors of programmed cell death (From Topology)	T: Bcl-2 inhibitors of programmed cell death	F: PF00452,PF02180	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (4.3.0)
B	1.10.437.10	Mainly Alpha	Orthogonal Bundle	Apoptosis Regulator Bcl-x	Blc2-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02180	Bcl-2 homology region 4 (BH4)	Bcl-2 homology region 4	-	Family
A, B	PF00452	Apoptosis regulator proteins, Bcl-2 family (Bcl-2)	Apoptosis regulator proteins, Bcl-2 family	-	Family
C, D	PF11430	Programmed cell death activator EGL-1 (EGL-1)	Programmed cell death activator EGL-1	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Apoptosis regulator ced-9	protein heterodimerization activity protein binding binding protein dimerization activity GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity molecular sequestering activity protein sequestering activity identical protein binding protein heterodimerization activity protein binding binding protein dimerization activity GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity molecular sequestering activity protein sequestering activity identical protein binding protein homodimerization activity	cellular component disassembly regulation of synapse pruning regulation of biological process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization cell junction disassembly synapse pruning biological regulation positive regulation of biological process positive regulation of synapse pruning cellular component organization regulation of synapse organization cell junction organization cellular component disassembly regulation of synapse pruning regulation of biological process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization cell junction disassembly synapse pruning biological regulation positive regulation of biological process positive regulation of synapse pruning cellular component organization regulation of synapse organization cell junction organization cellular process regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of biological quality positive regulation of cellular process apoptotic process involved in development developmental process anatomical structure development apoptotic process cell death programmed cell death negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death negative regulation of apoptotic process negative regulation of cellular process positive regulation of programmed cell death positive regulation of apoptotic process actin polymerization or depolymerization actin cytoskeleton organization protein-containing complex organization actin filament organization protein-containing complex disassembly actin filament depolymerization organelle organization actin filament-based process supramolecular fiber organization protein depolymerization cytoskeleton organization organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process biosynthetic process proteolysis organic substance biosynthetic process protein processing metabolic process protein metabolic process macromolecule metabolic process negative regulation of cellular component organization regulation of cellular component biogenesis negative regulation of protein-containing complex assembly cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly negative regulation of execution phase of apoptosis regulation of execution phase of apoptosis execution phase of apoptosis cellular response to stimulus signal transduction in absence of ligand response to stimulus cell surface receptor signaling pathway signaling extrinsic apoptotic signaling pathway cell communication apoptotic signaling pathway extrinsic apoptotic signaling pathway in absence of ligand signal transduction positive regulation of organelle organization regulation of developmental process positive regulation of developmental process regulation of mitochondrial fusion mitochondrial fusion regulation of anatomical structure morphogenesis positive regulation of mitochondrial fusion mitochondrion organization regulation of organelle organization organelle fusion anatomical structure morphogenesis regulation of mitochondrion organization intracellular signal transduction cellular response to stress DNA damage response response to stress intrinsic apoptotic signaling pathway in response to DNA damage intrinsic apoptotic signaling pathway biological process involved in interspecies interaction between organisms response to other organism defense response response to external stimulus defense response to Gram-negative bacterium response to biotic stimulus defense response to bacterium defense response to other organism response to bacterium response to external biotic stimulus sexual reproduction regulation of reproductive process reproductive process fertilization regulation of fertilization positive regulation of fertilization positive regulation of reproductive process multicellular organismal process regulation of embryonic development regulation of multicellular organismal development embryo development multicellular organism development positive regulation of embryonic development positive regulation of multicellular organismal process regulation of multicellular organismal process catabolic process macroautophagy autophagy cellular catabolic process mitophagy organelle disassembly autophagy of mitochondrion process utilizing autophagic mechanism egg-laying behavior multicellular organismal reproductive process regulation of egg-laying behavior regulation of behavior behavior positive regulation of behavior positive regulation of egg-laying behavior reproductive behavior multi-multicellular organism process positive regulation of brood size regulation of brood size	cellular anatomical entity endomembrane system membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle somatodendritic compartment cell body perikaryon neuronal cell body membrane cellular anatomical entity endomembrane system membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle somatodendritic compartment cell body perikaryon neuronal cell body membrane organelle membrane presynapse synapse cell junction perinuclear region of cytoplasm mitochondrial membrane organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane
C, D	EGg Laying defective EGL-1, programmed cell death activator	-	cellular component disassembly regulation of synapse pruning regulation of biological process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization cell junction disassembly synapse pruning biological regulation positive regulation of biological process positive regulation of synapse pruning cellular component organization regulation of synapse organization cell junction organization cellular component disassembly regulation of synapse pruning regulation of biological process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization cell junction disassembly synapse pruning biological regulation positive regulation of biological process positive regulation of synapse pruning cellular component organization regulation of synapse organization cell junction organization cellular process regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of biological quality positive regulation of cellular process organelle organization apoptotic mitochondrial changes apoptotic process cell death programmed cell death mitochondrion organization apoptotic process involved in development developmental process anatomical structure development positive regulation of programmed cell death regulation of programmed cell death protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis cellular component biogenesis positive regulation of protein-containing complex assembly regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly biological process involved in interspecies interaction between organisms response to stimulus response to other organism defense response response to external stimulus defense response to Gram-negative bacterium response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus regulation of apoptotic process positive regulation of apoptotic process regulation of development, heterochronic regulation of developmental process actin polymerization or depolymerization actin cytoskeleton organization actin filament organization protein-containing complex disassembly actin filament depolymerization actin filament-based process supramolecular fiber organization protein depolymerization cytoskeleton organization positive regulation of apoptotic process involved in development regulation of apoptotic process involved in development positive regulation of developmental process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle cytosol presynapse synapse cell junction

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036834	Bcl-2-like superfamily	Homologous Superfamily
A, B	IPR046371	Bcl-2, Bcl-2 homology region 1-3	Domain
A, B	IPR003093	Apoptosis regulator, Bcl-2 protein, BH4	Domain
A, B	IPR002475	Bcl2-like	Family
A, B	IPR026298	Bcl-2 family	Family
A, B	IPR020717	Apoptosis regulator, Bcl-2, BH1 motif, conserved site	Conserved Site
C, D	IPR021543	Programmed cell death activator EGL-1	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.