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Ovine recombinant PrP(114-234), ARQ variant in complex with the Fab of the VRQ14 antibody External Resource: Annotation Domain Annotation: SCOP2 Classification SCOP2 Database Homepage Chains Type Family Name Domain Identifier Family Identifier Provenance Source (Version) A SCOP2B Superfamily Prion-like 8035183 3001941 SCOP2B (2022-06-29)
Chains Family Name Domain Identifier Architecture Possible Homology Homology Topology Family Provenance Source (Version) A PF00377 e1tpxA1 A: a+b two layers X: Prion-like (From Topology) H: Prion-like (From Topology) T: Prion-like F: PF00377 ECOD (1.6) B PF07654 e1tpxB2 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: PF07654 ECOD (1.6) B PF07686 e1tpxB1 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: PF07686 ECOD (1.6) C PF07654 e1tpxC2 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: PF07654 ECOD (1.6) C PF07686 e1tpxC1 A: beta sandwiches X: Immunoglobulin-like beta-sandwich H: Immunoglobulin-related T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like F: PF07686 ECOD (1.6)
Chain Protein Name Description Organism Name Gene Allele Name(s) Domain Name(s) Receptor Type Receptor Description Provenance Source VRQ14 VH-CH1 Mus musculus (house mouse) IGHV9-3-1*01, IGHJ2*01, IGHG2A*01, IGHG2A*02 V-DOMAIN VH, C-DOMAIN CH1 IG FAB-GAMMA-2A_KAPPA IMGT (202418-0) VRQ14 L-KAPPA Mus musculus (house mouse) IGKV1-135*01, IGKJ1*01, IGKJ1*02, IGKJ2*01, IGKC*01, IGKC*02 V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA IG FAB-GAMMA-2A_KAPPA IMGT (202418-0)
Chain Chain Class Chain Subclass Chain Type Antigen Name(s) Provenance Source Heavy Chain IGHV9 - major prion protein SAbDab (2024-05-10) Light Chain IGKV1 Kappa major prion protein SAbDab (2024-05-10)
Chains Accession Name Description Comments Source PF00377 Prion/Doppel alpha-helical domain (Prion) Prion/Doppel alpha-helical domain The prion protein is thought to be the infectious agent that causes transmissible spongiform encephalopathies, such as scrapie and BSE. It is thought that the prion protein can exist in two different forms: one is the normal cellular protein, and the ... The prion protein is thought to be the infectious agent that causes transmissible spongiform encephalopathies, such as scrapie and BSE. It is thought that the prion protein can exist in two different forms: one is the normal cellular protein, and the other is the infectious form which can change the normal prion protein into the infectious form. It has been found that the prion alpha-helical domain is also found in the Doppel protein. Less Domain
Chains Polymer Molecular Function Biological Process Cellular Component major prion protein the VRQ14 Fab - - - the VRQ14 Fab - - -