1REG

CRYSTAL STRUCTURE OF THE T4 REGA TRANSLATIONAL REGULATOR PROTEIN AT 1.9 ANGSTROMS RESOLUTION

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth X]	d1regx_	Alpha and beta proteins (a+b)	Ferredoxin-like	Translational regulator protein regA	Translational regulator protein regA	Translational regulator protein regA	(Tequatrovirus T4 ) [TaxId: 10665 ],	SCOPe (2.08)
B [auth Y]	d1regy_	Alpha and beta proteins (a+b)	Ferredoxin-like	Translational regulator protein regA	Translational regulator protein regA	Translational regulator protein regA	(Tequatrovirus T4 ) [TaxId: 10665 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth X]	SCOP2 Family	Translational regulator protein regA	8023173	4001308	SCOP2 (2022-06-29)
A [auth X]	SCOP2 Superfamily	Translational regulator protein regA	8035553	3001253	SCOP2 (2022-06-29)
B [auth Y]	SCOP2B Superfamily	Translational regulator protein regA	8035553	3001253	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth X]	PF01818	e1regX1	A: a+b two layers	X: Alpha-beta plaits	H: Translational regulator protein regA (From Topology)	T: Translational regulator protein regA	F: PF01818	ECOD (1.6)
B [auth Y]	PF01818	e1regY1	A: a+b two layers	X: Alpha-beta plaits	H: Translational regulator protein regA (From Topology)	T: Translational regulator protein regA	F: PF01818	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth X]	3.30.70.650	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Translation repressor RegA	CATH (4.3.0)
B [auth Y]	3.30.70.650	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Translation repressor RegA	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth X], B [auth Y]	PF01818	Bacteriophage translational regulator (Translat_reg)	Bacteriophage translational regulator	The translational regulator protein regA is encoded by the T4 bacteriophage and binds to a region of messenger RNA (mRNA) that includes the initiator codon. RegA is unusual in that it represses the translation of about 35 early T4 mRNAs but does not ...	The translational regulator protein regA is encoded by the T4 bacteriophage and binds to a region of messenger RNA (mRNA) that includes the initiator codon. RegA is unusual in that it represses the translation of about 35 early T4 mRNAs but does not affect nearly 200 other mRNAs [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth X], B [auth Y]	T4 REGA	RNA binding binding organic cyclic compound binding nucleic acid binding	regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression organic substance metabolic process organic substance biosynthetic process protein metabolic process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process biological regulation regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression organic substance metabolic process organic substance biosynthetic process protein metabolic process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of translation regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth X], B [auth Y]	IPR036516	Translation repressor RegA superfamily	Homologous Superfamily
A [auth X], B [auth Y]	IPR002702	Translation repressor RegA	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.