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THE STRUCTURE OF THE RRNA METHYLTRANSFERASE ERMC': IMPLICATIONS FOR THE REACTION MECHANISM External Resource: Annotation Domain Annotation: SCOP2 Classification SCOP2 Database Homepage Chains Type Family Name Domain Identifier Family Identifier Provenance Source (Version) A SCOP2B Superfamily S13-like H2TH domain 8090704 3000053 SCOP2B (2022-06-29) A SCOP2B Superfamily S-adenosyl-L-methionine-dependent methyltransferases 8032286 3000118 SCOP2B (2022-06-29)
Chains Family Name Domain Identifier Architecture Possible Homology Homology Topology Family Provenance Source (Version) A PF00398 e1qaqA2 A: alpha arrays X: HhH/H2TH H: H2TH (From Topology) T: H2TH F: PF00398 ECOD (1.6) A PF00398 e1qaqA1 A: a/b three-layered sandwiches X: Rossmann-like H: Rossmann-related T: S-adenosyl-L-methionine-dependent methyltransferases F: PF00398 ECOD (1.6)
Chains Accession Short Name Description Provenance Source (Version) ARO:3000250 ErmC ErmC is a methyltransferase that catalyzes the methylation of A2058 of the 23S ribosomal RNA in two steps. Expression of ErmC is inducible by erythromycin. The leader peptide causes attenuation of the mRNA and stabilizes the structure preventing further translation. When erythromycin is present, it binds the leader peptide causing a change in conformation allowing for the expression of ErmC. CARD (3.2.9)
Chains Accession Gene Family Drug Class Resistance Machanism Provenance Source (Version) ARO:3000560 Erm 23S ribosomal RNA methyltransferase macrolide antibiotic, lincosamide antibiotic, streptogramin antibiotic, streptogramin A antibiotic, streptogramin B antibiotic antibiotic target alteration CARD (3.2.9)
Chains Polymer Molecular Function Biological Process Cellular Component ERMC' RRNA METHYLTRANSFERASE -