1QAJ

CRYSTAL STRUCTURES OF THE N-TERMINAL FRAGMENT FROM MOLONEY MURINE LEUKEMIA VIRUS REVERSE TRANSCRIPTASE COMPLEXED WITH NUCLEIC ACID: FUNCTIONAL IMPLICATIONS FOR TEMPLATE-PRIMER BINDING TO THE FINGERS DOMAIN

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth A]	d1qaja_	Multi-domain proteins (alpha and beta)	DNA/RNA polymerases	DNA/RNA polymerases	Reverse transcriptase	MMLV reverse transcriptase	(Moloney murine leukemia virus ) [TaxId: 11801 ],	SCOPe (2.08)
D [auth B]	d1qajb_	Multi-domain proteins (alpha and beta)	DNA/RNA polymerases	DNA/RNA polymerases	Reverse transcriptase	MMLV reverse transcriptase	(Moloney murine leukemia virus ) [TaxId: 11801 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2B Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8036265	3001272	SCOP2B (2022-06-29)
C [auth A]	SCOP2B Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8036265	3001272	SCOP2B (2022-06-29)
D [auth B]	SCOP2B Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8036265	3001272	SCOP2B (2022-06-29)
D [auth B]	SCOP2B Superfamily	Nucleotide cyclase/DNA polymerase palm domain-like	8036265	3001272	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth A]	RVT_1	e1qajA1	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: RVT_1	ECOD (1.6)
D [auth B]	RVT_1	e1qajB1	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: RVT_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth A]	3.10.10.10	Alpha Beta	Roll	HIV Type 1 Reverse Transcriptase	Chain A, domain 1	CATH (4.3.0)
C [auth A]	3.30.70.270	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Reverse transcriptase/Diguanylate cyclase domain	CATH (4.3.0)
D [auth B]	3.10.10.10	Alpha Beta	Roll	HIV Type 1 Reverse Transcriptase	Chain A, domain 1	CATH (4.3.0)
D [auth B]	3.30.70.270	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits	Reverse transcriptase/Diguanylate cyclase domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A], D [auth B]	PF00078	Reverse transcriptase (RNA-dependent DNA polymerase) (RVT_1)	Reverse transcriptase (RNA-dependent DNA polymerase)	A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs ...	A reverse transcriptase gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. Reverse transcriptases occur in a variety of mobile elements, including retrotransposons, retroviruses, group II introns, bacterial msDNAs, hepadnaviruses, and caulimoviruses.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth D]	DNA (5'-D(CPAPTPGPCPAPTPG)-3')	-	-	-
C [auth A], D [auth B]	REVERSE TRANSCRIPTASE	endonuclease activity retroviral integrase activity integrase activity catalytic activity, acting on a nucleic acid hydrolase activity DNA nuclease activity retroviral 3' processing activity DNA endonuclease activity catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds catalytic activity RNA binding binding endonuclease activity retroviral integrase activity integrase activity catalytic activity, acting on a nucleic acid hydrolase activity DNA nuclease activity retroviral 3' processing activity DNA endonuclease activity catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds catalytic activity RNA binding binding organic cyclic compound binding nucleic acid binding DNA-directed DNA polymerase activity DNA polymerase activity transferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups DNA binding aspartic-type peptidase activity peptidase activity catalytic activity, acting on a protein aspartic-type endopeptidase activity endopeptidase activity RNA endonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on RNA RNA-DNA hybrid ribonuclease activity RNA nuclease activity RNA endonuclease activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters RNA-directed DNA polymerase activity structural constituent of virion structural molecule activity cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	catabolic process primary metabolic process DNA metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleic acid metabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process DNA catabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process catabolic process primary metabolic process DNA metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleic acid metabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process DNA catabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process organic substance catabolic process virion assembly viral process viral life cycle establishment of integrated proviral latency viral latency establishment of viral latency viral genome integration into host DNA DNA recombination symbiont-mediated perturbation of host cellular process symbiont-mediated suppression of host gene expression biological process involved in interspecies interaction between organisms modulation by symbiont of host process symbiont-mediated perturbation of host gene expression cellular process modulation of process of another organism biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host organonitrogen compound metabolic process proteolysis protein metabolic process	membrane cellular anatomical entity host cell plasma membrane host cellular component host cell part host cell membrane host intracellular membrane-bounded organelle host intracellular part host multivesicular body host cell cytoplasm part host intracellular organelle host cell cytoplasm host cell late endosome host cell endosome membrane cellular anatomical entity host cell plasma membrane host cellular component host cell part host cell membrane host intracellular membrane-bounded organelle host intracellular part host multivesicular body host cell cytoplasm part host intracellular organelle host cell cytoplasm host cell late endosome host cell endosome host intracellular region host cell late endosome membrane host cell endosome membrane protein-containing complex protein-DNA complex viral nucleocapsid viral capsid virion component

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A], D [auth B]	IPR036397	Ribonuclease H superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR040643	Murine leukemia virus integrase, C-terminal	Domain
C [auth A], D [auth B]	IPR043128	Reverse transcriptase/Diguanylate cyclase domain	Homologous Superfamily
C [auth A], D [auth B]	IPR001995	Peptidase A2A, retrovirus, catalytic	Domain
C [auth A], D [auth B]	IPR001878	Zinc finger, CCHC-type	Domain
C [auth A], D [auth B]	IPR008919	Retrovirus capsid, N-terminal	Homologous Superfamily
C [auth A], D [auth B]	IPR010999	Retroviral matrix protein	Homologous Superfamily
C [auth A], D [auth B]	IPR021109	Aspartic peptidase domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR002079	Gag polyprotein, inner coat protein p12	Domain
C [auth A], D [auth B]	IPR001969	Aspartic peptidase, active site	Active Site
C [auth A], D [auth B]	IPR012337	Ribonuclease H-like superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR018061	Retropepsins	Domain
C [auth A], D [auth B]	IPR002156	Ribonuclease H domain	Domain
C [auth A], D [auth B]	IPR036875	Zinc finger, CCHC-type superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR000840	Gamma-retroviral matrix protein	Domain
C [auth A], D [auth B]	IPR001584	Integrase, catalytic core	Domain
C [auth A], D [auth B]	IPR041577	Reverse transcriptase/retrotransposon-derived protein, RNase H-like domain	Domain
C [auth A], D [auth B]	IPR043502	DNA/RNA polymerase superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR000477	Reverse transcriptase domain	Domain
C [auth A], D [auth B]	IPR036946	Gamma-retroviral matrix domain superfamily	Homologous Superfamily
C [auth A], D [auth B]	IPR039464	Gag-Pol polyprotein, Zinc-finger like domain	Domain
C [auth A], D [auth B]	IPR003036	Core shell protein Gag P30	Domain