Annotations: 1PDL

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1pdla_	Low resolution protein structures	Bacteriophage T4 3D cryo-EM reconstruction	Bacteriophage T4 3D cryo-EM reconstruction	Bacteriophage T4 3D cryo-EM reconstruction	Bacteriophage T4 3D cryo-EM reconstruction	(Tequatrovirus T4 ) [TaxId: 10665 ],	SCOPe (2.08)
B	d1pdlb_	Low resolution protein structures	Bacteriophage T4 3D cryo-EM reconstruction	Bacteriophage T4 3D cryo-EM reconstruction	Bacteriophage T4 3D cryo-EM reconstruction	Bacteriophage T4 3D cryo-EM reconstruction	(Tequatrovirus T4 ) [TaxId: 10665 ],	SCOPe (2.08)
C	d1pdlc_	Low resolution protein structures	Bacteriophage T4 3D cryo-EM reconstruction	Bacteriophage T4 3D cryo-EM reconstruction	Bacteriophage T4 3D cryo-EM reconstruction	Bacteriophage T4 3D cryo-EM reconstruction	(Tequatrovirus T4 ) [TaxId: 10665 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Lysozyme-like	8037749	3001879	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	gp5 N-terminal domain-like	8037745	3000235	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Phage fibre proteins	8037746	3000351	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	gp5 N-terminal domain-like	8037745	3000235	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Phage fibre proteins	8037746	3000351	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Lysozyme-like	8037749	3001879	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	gp5 N-terminal domain-like	8037745	3000235	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Lysozyme-like	8037749	3001879	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Phage fibre proteins	8037746	3000351	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF06714	e1pdlA3	A: beta barrels	X: OB-fold	H: Tail-associated lysozyme gp5-N (From Topology)	T: Tail-associated lysozyme gp5-N	F: PF06714	ECOD (1.6)
A	PF06715	e1pdlA2	A: beta duplicates or obligate multimers	X: Phage tail fiber protein trimerization domain (From Topology)	H: Phage tail fiber protein trimerization domain (From Topology)	T: Phage tail fiber protein trimerization domain	F: PF06715	ECOD (1.6)
A	PF00959,PF06714	e1pdlA1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: PF00959,PF06714	ECOD (1.6)
B	PF06714	e1pdlB3	A: beta barrels	X: OB-fold	H: Tail-associated lysozyme gp5-N (From Topology)	T: Tail-associated lysozyme gp5-N	F: PF06714	ECOD (1.6)
B	PF06715	e1pdlB2	A: beta duplicates or obligate multimers	X: Phage tail fiber protein trimerization domain (From Topology)	H: Phage tail fiber protein trimerization domain (From Topology)	T: Phage tail fiber protein trimerization domain	F: PF06715	ECOD (1.6)
B	PF00959,PF06714	e1pdlB1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: PF00959,PF06714	ECOD (1.6)
C	PF06714	e1pdlC3	A: beta barrels	X: OB-fold	H: Tail-associated lysozyme gp5-N (From Topology)	T: Tail-associated lysozyme gp5-N	F: PF06714	ECOD (1.6)
C	PF06715	e1pdlC2	A: beta duplicates or obligate multimers	X: Phage tail fiber protein trimerization domain (From Topology)	H: Phage tail fiber protein trimerization domain (From Topology)	T: Phage tail fiber protein trimerization domain	F: PF06715	ECOD (1.6)
C	PF00959,PF06714	e1pdlC1	A: a+b complex topology	X: Lysozyme-like (From Homology)	H: Lysozyme-like	T: Lysozyme-like	F: PF00959,PF06714	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C	PF00959	Phage lysozyme (Phage_lysozyme)	Phage lysozyme	This family includes lambda phage lysozyme and E. coli endolysin.	Domain
A, B, C	PF06715	Gp5 C-terminal repeat (3 copies) (Gp5_C)	Gp5 C-terminal repeat (3 copies)	-	Repeat
A, B, C	PF06714	Gp5 N-terminal OB domain (Gp5_OB)	Gp5 N-terminal OB domain	This domain is found at the N terminus of the Gp5 baseplate protein of bacteriophage T4. This domain binds to the Gp27 protein [1]. This domain has the common OB fold [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C	Tail-associated lysozyme	hydrolase activity, acting on glycosyl bonds peptidoglycan muralytic activity hydrolase activity, hydrolyzing O-glycosyl compounds lysozyme activity hydrolase activity catalytic activity identical protein binding protein binding binding	symbiont-mediated disruption of host anatomical structure biological process involved in interspecies interaction between organisms viral life cycle disruption of cell wall in another organism symbiont-mediated disruption of host cell wall symbiont-mediated disruption of host cell envelope biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell via disruption of host cell wall peptidoglycan disruption of cellular anatomical structure in another organism symbiont-mediated disruption of host cellular anatomical entity symbiont entry into host cell viral process symbiont entry into host symbiont-mediated disruption of host anatomical structure biological process involved in interspecies interaction between organisms viral life cycle disruption of cell wall in another organism symbiont-mediated disruption of host cell wall symbiont-mediated disruption of host cell envelope biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell via disruption of host cell wall peptidoglycan disruption of cellular anatomical structure in another organism symbiont-mediated disruption of host cellular anatomical entity symbiont entry into host cell viral process symbiont entry into host disruption of anatomical structure in another organism virion assembly viral tail assembly organic substance metabolic process catabolic process cell wall organization or biogenesis metabolic process cellular process macromolecule metabolic process organic substance catabolic process macromolecule catabolic process cell wall macromolecule catabolic process cell wall macromolecule metabolic process disruption of cell in another organism killing of cells of another organism cell killing symbiont entry into host cell via disruption of host cell envelope response to stimulus response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus organonitrogen compound catabolic process carbohydrate derivative catabolic process organonitrogen compound metabolic process peptidoglycan catabolic process glycosaminoglycan metabolic process carbohydrate derivative metabolic process aminoglycan catabolic process glycosaminoglycan catabolic process aminoglycan metabolic process peptidoglycan metabolic process	virus tail virion component virus tail, baseplate

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C	IPR009590	Protein Gp5, N-terminal OB-fold domain	Domain
A, B, C	IPR023347	Lysozyme domain superfamily	Homologous Superfamily
A, B, C	IPR023346	Lysozyme-like domain superfamily	Homologous Superfamily
A, B, C	IPR046397	Pre-baseplate central spike protein Gp5	Family
A, B, C	IPR001165	T4-type lysozyme	Family
A, B, C	IPR010609	Gp5, C-terminal	Repeat
A, B, C	IPR002196	Glycoside hydrolase, family 24	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.