1PD5

Crystal structure of E.coli chloramphenicol acetyltransferase type I at 2.5 Angstrom resolution

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
AMR Gene: CARD Annotation
AMR Gene Family: CARD Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E	d1pd5e_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	CAT-like	Chloramphenicol acetyltransferase, CAT	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
F	d1pd5f_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	CAT-like	Chloramphenicol acetyltransferase, CAT	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
G	d1pd5g_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	CAT-like	Chloramphenicol acetyltransferase, CAT	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
I	d1pd5i_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	CAT-like	Chloramphenicol acetyltransferase, CAT	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
J	d1pd5j_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	CAT-like	Chloramphenicol acetyltransferase, CAT	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
K	d1pd5k_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	CAT-like	Chloramphenicol acetyltransferase, CAT	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
L	d1pd5l_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	CAT-like	Chloramphenicol acetyltransferase, CAT	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
A	d1pd5a_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	CAT-like	Chloramphenicol acetyltransferase, CAT	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
B	d1pd5b_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	CAT-like	Chloramphenicol acetyltransferase, CAT	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
C	d1pd5c_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	CAT-like	Chloramphenicol acetyltransferase, CAT	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
D	d1pd5d_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	CAT-like	Chloramphenicol acetyltransferase, CAT	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)
H	d1pd5h_	Alpha and beta proteins (a/b)	CoA-dependent acyltransferases	CoA-dependent acyltransferases	CAT-like	Chloramphenicol acetyltransferase, CAT	(Escherichia coli ) [TaxId: 562 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E	SCOP2B Superfamily	CoA-dependent acyltransferases	8069085	3000272	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	CoA-dependent acyltransferases	8069085	3000272	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	CoA-dependent acyltransferases	8069085	3000272	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	CoA-dependent acyltransferases	8069085	3000272	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	CoA-dependent acyltransferases	8069085	3000272	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	CoA-dependent acyltransferases	8069085	3000272	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	CoA-dependent acyltransferases	8069085	3000272	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	CoA-dependent acyltransferases	8069085	3000272	SCOP2B (2022-06-29)
B	SCOP2 Family	CAT-like	8069084	4000430	SCOP2 (2022-06-29)
B	SCOP2 Superfamily	CoA-dependent acyltransferases	8069085	3000272	SCOP2 (2022-06-29)
C	SCOP2B Superfamily	CoA-dependent acyltransferases	8069085	3000272	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	CoA-dependent acyltransferases	8069085	3000272	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	CoA-dependent acyltransferases	8069085	3000272	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E	PF00302	e1pd5E1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: PF00302	ECOD (1.6)
F	PF00302	e1pd5F1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: PF00302	ECOD (1.6)
G	PF00302	e1pd5G1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: PF00302	ECOD (1.6)
I	PF00302	e1pd5I1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: PF00302	ECOD (1.6)
J	PF00302	e1pd5J1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: PF00302	ECOD (1.6)
K	PF00302	e1pd5K1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: PF00302	ECOD (1.6)
L	PF00302	e1pd5L1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: PF00302	ECOD (1.6)
A	PF00302	e1pd5A1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: PF00302	ECOD (1.6)
B	PF00302	e1pd5B1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: PF00302	ECOD (1.6)
C	PF00302	e1pd5C1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: PF00302	ECOD (1.6)
D	PF00302	e1pd5D1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: PF00302	ECOD (1.6)
H	PF00302	e1pd5H1	A: a+b complex topology	X: CoA-dependent acyltransferases (From Topology)	H: CoA-dependent acyltransferases (From Topology)	T: CoA-dependent acyltransferases	F: PF00302	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
F	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
G	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
I	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
J	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
K	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
L	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
A	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
B	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
C	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
D	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)
H	3.30.559.10	Alpha Beta	2-Layer Sandwich	Chloramphenicol Acetyltransferase	Chloramphenicol acetyltransferase-like domain	CATH (4.3.0)

AMR Gene: CARD Annotation CARD Database Homepage

Chains	Accession	Short Name	Description	Provenance Source (Version)
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	ARO:3002683	catA1	catA1 (formerly in CARD as catI) is a chromosome and transposon-encoded variant of the cat gene found in Escherichia coli and Acinetobacter baumannii.	CARD (3.2.9)

AMR Gene Family: CARD Annotation CARD Database Homepage

Chains	Accession	Gene Family	Drug Class	Resistance Machanism	Provenance Source (Version)
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	ARO:3000122	chloramphenicol acetyltransferase (CAT)	phenicol antibiotic	antibiotic inactivation	CARD (3.2.9)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	PF00302	Chloramphenicol acetyltransferase (CAT)	Chloramphenicol acetyltransferase	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	Chloramphenicol acetyltransferase	acetyltransferase activity O-acyltransferase activity acyltransferase activity O-acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity catalytic activity chloramphenicol O-acetyltransferase activity	response to stimulus response to chemical response to antibiotic	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR023213	Chloramphenicol acetyltransferase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR018372	Chloramphenicol acetyltransferase, active site	Active Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L	IPR001707	Chloramphenicol acetyltransferase	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.