Annotations: 1N0W

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1n0wa_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	RecA protein-like (ATPase-domain)	DNA repair protein Rad51, catalytic domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d1n0wb_	Peptides	BRCA2 BRC4 repeat	BRCA2 BRC4 repeat	BRCA2 BRC4 repeat	BRCA2 BRC4 repeat	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	RecA/Rad51/KaiC-like ATPases	8018169	4004007	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	RecA-like P-loop NTPases	8056644	3002019	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RecA	e1n0wA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: RecA	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF08423	Rad51 (Rad51)	Rad51	Rad51 is a DNA repair and recombination protein and is a homologue of the bacterial ATPase RecA protein.	Domain
B	PF00634	BRCA2 repeat (BRCA2)	BRCA2 repeat	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DNA repair protein RAD51 homolog 1	ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity DNA strand exchange activity DNA damage sensor activity small molecule sensor activity ATP-dependent DNA damage sensor activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid catalytic activity ATP-dependent activity DNA strand exchange activity DNA damage sensor activity small molecule sensor activity ATP-dependent DNA damage sensor activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding identical protein binding protein binding protein-containing complex binding chromatin binding DNA binding double-stranded DNA binding nucleic acid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides DNA helicase activity single-stranded DNA helicase activity helicase activity DNA polymerase binding enzyme binding single-stranded DNA binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of DNA recombination regulation of cellular process regulation of double-strand break repair regulation of cellular response to stress regulation of primary metabolic process nucleobase-containing compound metabolic process organic substance metabolic process regulation of response to stress cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process regulation of DNA recombination regulation of cellular process regulation of double-strand break repair regulation of cellular response to stress regulation of primary metabolic process nucleobase-containing compound metabolic process organic substance metabolic process regulation of response to stress recombinational repair regulation of nucleobase-containing compound metabolic process double-strand break repair via homologous recombination DNA repair double-strand break repair regulation of biological process DNA recombination biological regulation primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of DNA repair regulation of double-strand break repair via homologous recombination organic cyclic compound metabolic process regulation of response to stimulus metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process DNA-templated DNA replication DNA-templated DNA replication maintenance of fidelity DNA replication replication fork processing cellular response to nitrogen compound response to organic substance response to alkaloid cellular response to endogenous stimulus cellular response to camptothecin cellular response to organic substance cellular response to alkaloid response to organic cyclic compound response to alcohol response to organonitrogen compound response to endogenous stimulus cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to alcohol cellular response to organonitrogen compound response to camptothecin response to chemical homologous recombination sexual reproduction reproductive process meiotic cell cycle process cellular component organization meiosis I meiotic nuclear division cell cycle cellular component organization or biogenesis reciprocal homologous recombination cell cycle process meiotic cell cycle organelle fission reciprocal meiotic recombination nuclear division organelle organization meiosis I cell cycle process response to ionizing radiation cellular response to ionizing radiation response to radiation response to abiotic stimulus cellular response to radiation cellular response to abiotic stimulus cellular response to environmental stimulus interstrand cross-link repair DNA damage checkpoint signaling regulation of cell cycle phase transition signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition regulation of signal transduction intracellular signal transduction cell communication regulation of cell cycle checkpoint regulation of intracellular signal transduction negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction regulation of cell cycle regulation of signaling regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling signal transduction in response to DNA damage regulation of cell communication regulation of DNA damage checkpoint DNA strand invasion cellular component biogenesis protein-DNA complex organization DNA recombinase assembly cellular component assembly protein-containing complex assembly DNA repair complex assembly protein-containing complex organization protein-DNA complex assembly double-strand break repair via synthesis-dependent strand annealing double-strand break repair involved in meiotic recombination replication-born double-strand break repair via sister chromatid exchange chromosome organization chromosome organization involved in meiotic cell cycle mitotic recombination telomere organization telomere maintenance telomere maintenance via recombination mitotic DNA replication nuclear DNA replication cell cycle DNA replication mitotic cell cycle cell cycle DNA replication maintenance of fidelity mitotic cell cycle process mitotic recombination-dependent replication fork processing mitotic DNA replication maintenance of fidelity regulation of protein modification process regulation of protein phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process organonitrogen compound metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process cellular metabolic process regulation of cellular metabolic process macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process positive regulation of biological process DNA ligation positive regulation of metabolic process regulation of DNA ligation positive regulation of DNA ligation positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of DNA metabolic process cellular response to inorganic substance response to inorganic substance cellular response to hydroxyurea response to hydroxyurea telomere maintenance via telomere lengthening DNA duplex unwinding DNA geometric change DNA conformation change DNA unwinding involved in DNA replication	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle synapse intermediate filament cytoskeleton intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle synapse intermediate filament cytoskeleton presynaptic cytoskeleton presynapse cytoskeleton cell junction presynaptic intermediate filament cytoskeleton membrane-bounded organelle nucleus membrane-enclosed lumen nuclear chromosome intracellular membrane-bounded organelle intracellular organelle lumen organelle lumen nuclear lumen perinuclear region of cytoplasm male germ cell nucleus germ cell nucleus chromosome, telomeric region chromosomal region ubiquitin ligase complex catalytic complex nuclear protein-containing complex transferase complex nuclear ubiquitin ligase complex intracellular protein-containing complex mitochondrion nucleolus condensed chromosome condensed nuclear chromosome centrosome microtubule organizing center microtubule cytoskeleton nucleoplasm lateral element synaptonemal structure synaptonemal complex site of double-strand break site of DNA damage mitochondrial matrix nuclear body PML body
B	Breast cancer type 2 susceptibility protein	catalytic activity, acting on a protein N-acetyltransferase activity acyltransferase activity histone H3 acetyltransferase activity transferase activity peptide N-acetyltransferase activity histone acetyltransferase activity acetyltransferase activity peptide-lysine-N-acetyltransferase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity identical protein binding catalytic activity, acting on a protein N-acetyltransferase activity acyltransferase activity histone H3 acetyltransferase activity transferase activity peptide N-acetyltransferase activity histone acetyltransferase activity acetyltransferase activity peptide-lysine-N-acetyltransferase activity histone modifying activity acyltransferase activity, transferring groups other than amino-acyl groups catalytic activity N-acyltransferase activity identical protein binding protein binding binding enzyme binding protease binding cytoskeletal protein binding gamma-tubulin binding tubulin binding histone H4 acetyltransferase activity DNA binding organic cyclic compound binding single-stranded DNA binding nucleic acid binding	developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process multicellular organism development multicellular organismal process head development central nervous system development developmental process stem cell proliferation cell population proliferation cellular developmental process hemopoiesis cell differentiation anatomical structure development hematopoietic stem cell proliferation cell development cellular process multicellular organism development multicellular organismal process head development central nervous system development animal organ development brain development nervous system development system development spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation response to X-ray response to ionizing radiation response to stimulus response to radiation response to abiotic stimulus microtubule organizing center organization microtubule cytoskeleton organization cellular component organization centrosome duplication organelle organization centrosome cycle microtubule-based process cell cycle cellular component organization or biogenesis cytoskeleton organization cell cycle process cellular response to stimulus cellular response to ionizing radiation cellular response to radiation cellular response to abiotic stimulus cellular response to environmental stimulus DNA damage checkpoint signaling regulation of cellular process regulation of cell cycle phase transition signaling negative regulation of biological process regulation of cellular response to stress negative regulation of cell cycle cell cycle phase transition regulation of signal transduction intracellular signal transduction cell communication regulation of cell cycle checkpoint cellular response to stress regulation of intracellular signal transduction response to stress regulation of response to stress negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction regulation of cell cycle regulation of biological process regulation of signaling regulation of cell cycle process biological regulation DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling DNA damage response regulation of response to stimulus signal transduction in response to DNA damage regulation of cell communication regulation of DNA damage checkpoint cellular metabolic process cellular senescence metabolic process inner cell mass cell proliferation developmental growth chordate embryonic development growth embryo development in utero embryonic development embryo development ending in birth or egg hatching blastocyst growth blastocyst development oogenesis cellular process involved in reproduction in multicellular organism developmental maturation female gamete generation oocyte development anatomical structure maturation germ cell development oocyte maturation oocyte differentiation cell maturation regulation of cytokinesis cytokinesis regulation of cell division cell division cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process DNA metabolic process nucleotide-excision repair DNA repair gonad development reproductive system development female gonad development sex differentiation female sex differentiation development of primary female sexual characteristics development of primary sexual characteristics reproductive structure development DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator signal transduction by p53 class mediator DNA damage response, signal transduction by p53 class mediator DNA damage response, signal transduction resulting in transcription DNA recombination mitotic recombination telomere organization chromosome organization telomere maintenance telomere maintenance via recombination mammary gland development gland development negative regulation of mammary gland epithelial cell proliferation regulation of multicellular organismal process epithelial cell proliferation negative regulation of cell population proliferation epithelium development tissue development regulation of mammary gland epithelial cell proliferation mammary gland epithelium development regulation of cell population proliferation regulation of epithelial cell proliferation negative regulation of multicellular organismal process negative regulation of epithelial cell proliferation mammary gland epithelial cell proliferation establishment of protein localization to telomere protein localization establishment of protein localization cellular localization protein localization to chromosome, telomeric region establishment of localization localization establishment of protein localization to organelle protein localization to chromosome cellular macromolecule localization macromolecule localization protein localization to organelle establishment of protein localization to chromosome mitotic DNA replication DNA-templated DNA replication maintenance of fidelity nuclear DNA replication cell cycle DNA replication mitotic cell cycle cell cycle DNA replication maintenance of fidelity DNA-templated DNA replication DNA replication mitotic cell cycle process mitotic recombination-dependent replication fork processing mitotic DNA replication maintenance of fidelity replication fork processing double-strand break repair recombinational repair double-strand break repair via homologous recombination positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process response to gamma radiation cell death intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator apoptotic signaling pathway intrinsic apoptotic signaling pathway by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage apoptotic process intrinsic apoptotic signaling pathway programmed cell death male meiosis I organelle fission meiotic cell cycle male meiotic nuclear division meiotic cell cycle process nuclear division meiosis I meiosis I cell cycle process meiotic nuclear division positive regulation of cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle response to light stimulus response to UV-C response to UV	protein-containing complex catalytic complex DNA repair complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle protein-containing complex catalytic complex DNA repair complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane-bounded organelle intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle organelle secretory granule secretory vesicle vesicle intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region chromosomal region non-membrane-bounded organelle ubiquitin ligase complex nucleus nuclear protein-containing complex transferase complex nuclear ubiquitin ligase complex intracellular protein-containing complex BRCA2-MAGE-D1 complex centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen condensed nuclear chromosome nuclear chromosome lateral element synaptonemal structure synaptonemal complex condensed chromosome
C [auth L]	peptide linker	-	-	-
D [auth C]	ARTIFICIAL GLY-SER-MSE-GLY PEPTIDE	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR013632	DNA recombination and repair protein Rad51-like, C-terminal	Domain
A	IPR020587	DNA recombination and repair protein RecA, monomer-monomer interface	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR020588	DNA recombination and repair protein RecA-like, ATP-binding domain	Domain
A	IPR003593	AAA+ ATPase domain	Domain
A	IPR011941	DNA recombination/repair protein Rad51	Family
A	IPR016467	DNA recombination and repair protein, RecA-like	Family
A	IPR010995	DNA repair Rad51/transcription factor NusA, alpha-helical	Homologous Superfamily
B	IPR036315	BRCA2 helical domain superfamily	Homologous Superfamily
B	IPR048262	BRCA2, OB2 domain	Domain
B	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
B	IPR015525	Breast cancer type 2 susceptibility protein	Family
B	IPR015187	BRCA2, OB1	Domain
B	IPR015252	Breast cancer type 2 susceptibility protein, helical domain	Domain
B	IPR015188	BRCA2, OB3	Domain
B	IPR015205	Tower domain	Domain
B	IPR002093	BRCA2 repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q06609	Fanconi anemia mirror movements 2 breast cancer breast carcinoma Fanconi anemia complementation group R head and neck cancer Micronuclei, Chromosome-Defective invasive ductal breast carcinoma malignant glioma malignant tumor of neck medulloblastoma neoplasm of neck aplastic anemia ovarian cancer pancreatic intraductal papillary-mucinous neoplasm Fanconi anemia mirror movements 2 breast cancer breast carcinoma Fanconi anemia complementation group R head and neck cancer Micronuclei, Chromosome-Defective invasive ductal breast carcinoma malignant glioma malignant tumor of neck medulloblastoma neoplasm of neck aplastic anemia ovarian cancer pancreatic intraductal papillary-mucinous neoplasm cancer psoriasis hereditary breast carcinoma inherited aplastic anemia large cell medulloblastoma malignant mesothelioma non-small cell lung carcinoma atypical teratoid rhabdoid tumor ovarian disease primitive neuroectodermal tumor head and neck neoplasm hereditary breast ovarian cancer syndrome inherited disease susceptibility lung cancer osteosarcoma pancreatic intraductal papillary-mucinous carcinoma breast disease prostate carcinoma familial congenital mirror movements glioblastoma IgA glomerulonephritis
B	Pharos: P51587	prostate cancer Fanconi anemia medulloblastoma breast cancer malignant glioma Fanconi anemia complementation group D1 ovarian cancer kidney Wilms tumor lung carcinoma hereditary breast ovarian cancer syndrome breast carcinoma breast-ovarian cancer, familial, susceptibility to, 2 exocrine pancreatic carcinoma malignant pancreatic neoplasm glioma susceptibility 3 prostate cancer Fanconi anemia medulloblastoma breast cancer malignant glioma Fanconi anemia complementation group D1 ovarian cancer kidney Wilms tumor lung carcinoma hereditary breast ovarian cancer syndrome breast carcinoma breast-ovarian cancer, familial, susceptibility to, 2 exocrine pancreatic carcinoma malignant pancreatic neoplasm glioma susceptibility 3 cancer adult medulloblastoma melanotic medulloblastoma squamous cell neoplasm ovarian carcinoma pancreatic cancer, susceptibility to, 2 familial prostate carcinoma squamous cell carcinoma medullomyoblastoma with myogenic differentiation mixed glioma childhood medulloblastoma Perlman syndrome congenital anemia Lynch syndrome prostate adenocarcinoma Esophageal atresia with or without tracheoesophageal fistula malignant mesothelioma schizophrenia acute lymphoblastic leukemia skin basal cell carcinoma melanoma aplastic anemia squamous cell lung carcinoma myocardial infarction benign neoplasm of pancreas Wilms tumor 1 hereditary breast carcinoma neurofibromatosis type 1 breast adenocarcinoma inherited aplastic anemia ovarian neoplasm lung adenocarcinoma peripheral nervous system disease cholangiocarcinoma malignant colon neoplasm esophageal atresia/tracheoesophageal fistula psoriasis familial pancreatic carcinoma serous adenocarcinoma Fanconi anemia complementation group A small cell lung carcinoma glioblastoma atypical teratoid rhabdoid tumor heart disease osteosarcoma intellectual disability large cell medulloblastoma carcinoma lung benign neoplasm peripheral neuropathy colorectal cancer primitive neuroectodermal tumor desmoplastic/nodular medulloblastoma prostate carcinoma estrogen-receptor negative breast cancer Sjogren syndrome anemia glioma BAP1-related tumor predisposition syndrome urinary bladder cancer hematopoietic and lymphoid system neoplasm bipolar disorder hereditary Wilms tumor isolated growth hormone deficiency type IA ovarian endometrioid adenocarcinoma Li-Fraumeni syndrome pancreatic neoplasm lung cancer

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.