1MYL

SUBSTITUTING HYDROPHOBIC RESIDUES FOR A BURIED SALT BRIDGE ENHANCES PROTEIN STABILITY BUT DOES NOT REDUCE CONFORMATIONAL SPECIFICITY

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1myla_	All alpha proteins	Ribbon-helix-helix	Ribbon-helix-helix	Arc/Mnt-like phage repressors	Arc repressor	(Lederbergvirus P22 ) [TaxId: 10754 ],	SCOPe (2.08)
B	d1mylb_	All alpha proteins	Ribbon-helix-helix	Ribbon-helix-helix	Arc/Mnt-like phage repressors	Arc repressor	(Lederbergvirus P22 ) [TaxId: 10754 ],	SCOPe (2.08)
C	d1mylc_	All alpha proteins	Ribbon-helix-helix	Ribbon-helix-helix	Arc/Mnt-like phage repressors	Arc repressor	(Lederbergvirus P22 ) [TaxId: 10754 ],	SCOPe (2.08)
D	d1myld_	All alpha proteins	Ribbon-helix-helix	Ribbon-helix-helix	Arc/Mnt-like phage repressors	Arc repressor	(Lederbergvirus P22 ) [TaxId: 10754 ],	SCOPe (2.08)
E	d1myle_	All alpha proteins	Ribbon-helix-helix	Ribbon-helix-helix	Arc/Mnt-like phage repressors	Arc repressor	(Lederbergvirus P22 ) [TaxId: 10754 ],	SCOPe (2.08)
F	d1mylf_	All alpha proteins	Ribbon-helix-helix	Ribbon-helix-helix	Arc/Mnt-like phage repressors	Arc repressor	(Lederbergvirus P22 ) [TaxId: 10754 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ribbon-helix-helix	8037416	3000295	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ribbon-helix-helix	8037416	3000295	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Ribbon-helix-helix	8037416	3000295	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Arc	e1mylA1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: Arc	ECOD (1.6)
B	Arc	e1mylB1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: Arc	ECOD (1.6)
C	Arc	e1mylC1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: Arc	ECOD (1.6)
D	Arc	e1mylD1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: Arc	ECOD (1.6)
E	Arc	e1mylE1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: Arc	ECOD (1.6)
F	Arc	e1mylF1	A: alpha arrays	X: HTH	H: HTH	T: Ribbon-helix-helix	F: Arc	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.1220.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant	Met repressor-like	CATH (4.3.0)
B	1.10.1220.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant	Met repressor-like	CATH (4.3.0)
C	1.10.1220.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant	Met repressor-like	CATH (4.3.0)
D	1.10.1220.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant	Met repressor-like	CATH (4.3.0)
E	1.10.1220.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant	Met repressor-like	CATH (4.3.0)
F	1.10.1220.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant	Met repressor-like	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F	PF03869	Arc-like DNA binding domain (Arc)	Arc-like DNA binding domain	Arc repressor act by he cooperative binding of two Arc repressor dimers to a 21-base-pair operator site. Each Arc dimer uses an antiparallel beta-sheet to recognise bases in the major groove [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F	ARC REPRESSOR	DNA binding binding organic cyclic compound binding nucleic acid binding	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F	IPR013321	Arc-type ribbon-helix-helix	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR010985	Ribbon-helix-helix	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F	IPR005569	Arc-like DNA binding domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.