1KUW

High-Resolution Structure and Localization of Amylin Nucleation Site in Detergent Micelles

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1kuwa_	Peptides	Amyloid peptides	Amyloid peptides	Amyloid peptides	Islet amyloid polypeptide	( ) [TaxId: ], (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00214	Calcitonin / CGRP / IAPP family (Calc_CGRP_IAPP)	Calcitonin / CGRP / IAPP family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Islet amyloid polypeptide	protein binding binding signaling receptor binding amide binding amyloid-beta binding peptide binding molecular function activator activity molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity hormone activity lipid binding identical protein binding	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of calcium-mediated signaling cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette regulation of calcium-mediated signaling positive regulation of calcium-mediated signaling signal transduction positive regulation of cellular process regulation of biological process regulation of signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus calcium-mediated signaling regulation of cell communication cellular process positive regulation of signaling apoptotic process cell death programmed cell death positive regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death positive regulation of apoptotic process cAMP-mediated signaling positive regulation of cAMP-mediated signaling regulation of cAMP-mediated signaling behavior multicellular organismal process eating behavior feeding behavior cell-cell signaling regulation of cellular component organization negative regulation of cellular component organization protein-containing complex organization negative regulation of biological process regulation of cellular component biogenesis negative regulation of protein-containing complex assembly cellular component organization cellular component biogenesis regulation of protein-containing complex assembly cellular component assembly protein-containing complex assembly negative regulation of cellular process cellular component organization or biogenesis myeloid leukocyte differentiation regulation of leukocyte differentiation cellular developmental process regulation of developmental process cell development regulation of cell differentiation regulation of cell development regulation of osteoclast differentiation multicellular organism development cell differentiation osteoclast differentiation anatomical structure development regulation of immune system process regulation of multicellular organismal process negative regulation of cell differentiation negative regulation of hemopoiesis developmental process regulation of multicellular organismal development negative regulation of leukocyte differentiation hemopoiesis regulation of myeloid cell differentiation negative regulation of developmental process regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of osteoclast differentiation negative regulation of myeloid leukocyte differentiation negative regulation of cell development myeloid cell differentiation negative regulation of immune system process immune system process regulation of hemopoiesis negative regulation of multicellular organismal process leukocyte differentiation positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade negative regulation of tissue remodeling homeostatic process negative regulation of bone remodeling regulation of bone remodeling tissue homeostasis regulation of tissue remodeling regulation of bone resorption bone resorption negative regulation of bone resorption multicellular organismal-level homeostasis tissue remodeling bone remodeling anatomical structure homeostasis regulation of protein kinase A signaling protein kinase A signaling positive regulation of protein kinase A signaling amylin receptor signaling pathway calcitonin family receptor signaling pathway G protein-coupled receptor signaling pathway system process sensory perception nervous system process sensory perception of pain negative regulation of amyloid fibril formation regulation of amyloid fibril formation amyloid fibril formation regulation of primary metabolic process organic substance metabolic process protein metabolic process negative regulation of supramolecular fiber organization negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound metabolic process regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process regulation of supramolecular fiber organization metabolic process macromolecule metabolic process supramolecular fiber organization regulation of metabolic process	extracellular region cellular anatomical entity extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR018360	Calcitonin, conserved site	Conserved Site
A	IPR000443	Islet amyloid polypeptide	Family
A	IPR021117	Calcitonin-like	Family
A	IPR001693	Calcitonin peptide-like	Domain
A	IPR021116	Calcitonin/adrenomedullin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P10997	type 2 diabetes mellitus Diabetes Mellitus, Experimental gastric ulcer maturity-onset diabetes of the young pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Alzheimer disease inborn carbohydrate metabolic disorder pancreatic intraductal papillary-mucinous carcinoma amyloidosis malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous neoplasm

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.