1KNZ

Recognition of the rotavirus mRNA 3' consensus by an asymmetric NSP3 homodimer

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E [auth A]	d1knza_	Multi-domain proteins (alpha and beta)	NSP3 homodimer	NSP3 homodimer	NSP3 homodimer	NSP3 homodimer	(Simian rotavirus A/SA11 ) [TaxId: 10923 ],	SCOPe (2.08)
F [auth B]	d1knzb1	Multi-domain proteins (alpha and beta)	NSP3 homodimer	NSP3 homodimer	NSP3 homodimer	NSP3 homodimer	(Simian rotavirus A/SA11 ) [TaxId: 10923 ],	SCOPe (2.08)
F [auth B]	d1knzb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Simian rotavirus A/SA11 ) [TaxId: 10923 ],	SCOPe (2.08)
G [auth C]	d1knzc_	Multi-domain proteins (alpha and beta)	NSP3 homodimer	NSP3 homodimer	NSP3 homodimer	NSP3 homodimer	(Simian rotavirus A/SA11 ) [TaxId: 10923 ],	SCOPe (2.08)
H [auth D]	d1knzd1	Multi-domain proteins (alpha and beta)	NSP3 homodimer	NSP3 homodimer	NSP3 homodimer	NSP3 homodimer	(Simian rotavirus A/SA11 ) [TaxId: 10923 ],	SCOPe (2.08)
H [auth D]	d1knzd2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Simian rotavirus A/SA11 ) [TaxId: 10923 ],	SCOPe (2.08)
I	d1knzi_	Multi-domain proteins (alpha and beta)	NSP3 homodimer	NSP3 homodimer	NSP3 homodimer	NSP3 homodimer	(Simian rotavirus A/SA11 ) [TaxId: 10923 ],	SCOPe (2.08)
J	d1knzj1	Multi-domain proteins (alpha and beta)	NSP3 homodimer	NSP3 homodimer	NSP3 homodimer	NSP3 homodimer	(Simian rotavirus A/SA11 ) [TaxId: 10923 ],	SCOPe (2.08)
J	d1knzj2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Simian rotavirus A/SA11 ) [TaxId: 10923 ],	SCOPe (2.08)
K [auth M]	d1knzm_	Multi-domain proteins (alpha and beta)	NSP3 homodimer	NSP3 homodimer	NSP3 homodimer	NSP3 homodimer	(Simian rotavirus A/SA11 ) [TaxId: 10923 ],	SCOPe (2.08)
L [auth N]	d1knzn1	Multi-domain proteins (alpha and beta)	NSP3 homodimer	NSP3 homodimer	NSP3 homodimer	NSP3 homodimer	(Simian rotavirus A/SA11 ) [TaxId: 10923 ],	SCOPe (2.08)
L [auth N]	d1knzn2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Simian rotavirus A/SA11 ) [TaxId: 10923 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E [auth A]	SCOP2 Family	Rotavirus NSP3 RNA-binding domain	8025945	4003594	SCOP2 (2022-06-29)
E [auth A]	SCOP2 Superfamily	Rotavirus NSP3 RNA-binding domain	8038324	3001095	SCOP2 (2022-06-29)
F [auth B]	SCOP2B Superfamily	Rotavirus NSP3 RNA-binding domain	8038324	3001095	SCOP2B (2022-06-29)
G [auth C]	SCOP2B Superfamily	Rotavirus NSP3 RNA-binding domain	8038324	3001095	SCOP2B (2022-06-29)
H [auth D]	SCOP2B Superfamily	Rotavirus NSP3 RNA-binding domain	8038324	3001095	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Rotavirus NSP3 RNA-binding domain	8038324	3001095	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Rotavirus NSP3 RNA-binding domain	8038324	3001095	SCOP2B (2022-06-29)
K [auth M]	SCOP2B Superfamily	Rotavirus NSP3 RNA-binding domain	8038324	3001095	SCOP2B (2022-06-29)
L [auth N]	SCOP2B Superfamily	Rotavirus NSP3 RNA-binding domain	8038324	3001095	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth A]	Rota_NSP3	e1knzA1	A: a+b duplicates or obligate multimers	X: NSP3 homodimer (From Topology)	H: NSP3 homodimer (From Topology)	T: NSP3 homodimer	F: Rota_NSP3	ECOD (1.6)
F [auth B]	Rota_NSP3	e1knzB1	A: a+b duplicates or obligate multimers	X: NSP3 homodimer (From Topology)	H: NSP3 homodimer (From Topology)	T: NSP3 homodimer	F: Rota_NSP3	ECOD (1.6)
G [auth C]	Rota_NSP3	e1knzC1	A: a+b duplicates or obligate multimers	X: NSP3 homodimer (From Topology)	H: NSP3 homodimer (From Topology)	T: NSP3 homodimer	F: Rota_NSP3	ECOD (1.6)
H [auth D]	Rota_NSP3	e1knzD2	A: a+b duplicates or obligate multimers	X: NSP3 homodimer (From Topology)	H: NSP3 homodimer (From Topology)	T: NSP3 homodimer	F: Rota_NSP3	ECOD (1.6)
I	Rota_NSP3	e1knzI1	A: a+b duplicates or obligate multimers	X: NSP3 homodimer (From Topology)	H: NSP3 homodimer (From Topology)	T: NSP3 homodimer	F: Rota_NSP3	ECOD (1.6)
J	Rota_NSP3	e1knzJ2	A: a+b duplicates or obligate multimers	X: NSP3 homodimer (From Topology)	H: NSP3 homodimer (From Topology)	T: NSP3 homodimer	F: Rota_NSP3	ECOD (1.6)
K [auth M]	Rota_NSP3	e1knzM1	A: a+b duplicates or obligate multimers	X: NSP3 homodimer (From Topology)	H: NSP3 homodimer (From Topology)	T: NSP3 homodimer	F: Rota_NSP3	ECOD (1.6)
L [auth N]	Rota_NSP3	e1knzN2	A: a+b duplicates or obligate multimers	X: NSP3 homodimer (From Topology)	H: NSP3 homodimer (From Topology)	T: NSP3 homodimer	F: Rota_NSP3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth A]	6.10.280.20	Special	Helix non-globular	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
E [auth A]	3.30.70.1610	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
F [auth B]	6.10.280.20	Special	Helix non-globular	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
F [auth B]	3.30.70.1610	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
G [auth C]	6.10.280.20	Special	Helix non-globular	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
G [auth C]	3.30.70.1610	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
H [auth D]	6.10.280.20	Special	Helix non-globular	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
H [auth D]	3.30.70.1610	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
I	6.10.280.20	Special	Helix non-globular	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
I	3.30.70.1610	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
J	6.10.280.20	Special	Helix non-globular	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
J	3.30.70.1610	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
K [auth M]	6.10.280.20	Special	Helix non-globular	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
K [auth M]	3.30.70.1610	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)
L [auth N]	6.10.280.20	Special	Helix non-globular	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)
L [auth N]	3.30.70.1610	Alpha Beta	2-Layer Sandwich	Alpha-Beta Plaits		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
E [auth A], F [auth B], G [auth C], H [auth D], I, E [auth A], F [auth B], G [auth C], H [auth D], I, J, K [auth M], L [auth N]	PF01665	Rotavirus non-structural protein NSP3 (Rota_NSP3)	Rotavirus non-structural protein NSP3	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth W], B [auth X], C [auth Y], D [auth Z]	5'-R(UPGPAPCP*C)-3'	-	-	-
E [auth A], F [auth B], G [auth C], H [auth D], I, E [auth A], F [auth B], G [auth C], H [auth D], I, J, K [auth M], L [auth N]	Nonstructural RNA-binding Protein 34	RNA binding binding organic cyclic compound binding nucleic acid binding	regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression organic substance metabolic process organic substance biosynthetic process protein metabolic process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process biological regulation regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process regulation of primary metabolic process post-transcriptional regulation of gene expression organic substance metabolic process organic substance biosynthetic process protein metabolic process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of translation regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process	host cellular component host intracellular part host cell cytoplasm host cell part host intracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
E [auth A], F [auth B], G [auth C], H [auth D], I, E [auth A], F [auth B], G [auth C], H [auth D], I, J, K [auth M], L [auth N]	IPR042519	Non-structural protein NSP3, N-terminal, rotavirus	Homologous Superfamily
E [auth A], F [auth B], G [auth C], H [auth D], I, E [auth A], F [auth B], G [auth C], H [auth D], I, J, K [auth M], L [auth N]	IPR002873	Rotavirus non-structural protein NSP3	Family
E [auth A], F [auth B], G [auth C], H [auth D], I, E [auth A], F [auth B], G [auth C], H [auth D], I, J, K [auth M], L [auth N]	IPR036082	NSP3 superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.