Navigation Tabs
CRYSTAL STRUCTURES OF FELINE IMMUNODEFICIENCY VIRUS DUTP PYROPHOSPHATASE AND ITS NUCLEOTIDE COMPLEXES IN THREE CRYSTAL FORMS External Resource: Annotation Domain Annotation: SCOP2 Classification SCOP2 Database Homepage Chains Type Family Name Domain Identifier Family Identifier Provenance Source (Version) A SCOP2 Family dUTPase-like 8030758 4002970 SCOP2 (2022-06-29) A SCOP2 Superfamily dUTPase-like 8043137 3001957 SCOP2 (2022-06-29) B SCOP2B Superfamily dUTPase-like 8043137 3001957 SCOP2B (2022-06-29)
Chains Family Name Domain Identifier Architecture Possible Homology Homology Topology Family Provenance Source (Version) A PF00692 e1f7dA1 A: beta barrels X: beta-clip H: dUTPase-like (From Topology) T: dUTPase-like F: PF00692 ECOD (1.6) B PF00692 e1f7dB1 A: beta barrels X: beta-clip H: dUTPase-like (From Topology) T: dUTPase-like F: PF00692 ECOD (1.6)
Chains Accession Name Description Comments Source PF00075 RNase H (RNase_H) RNase H RNase H digests the RNA strand of an RNA/DNA hybrid. Important enzyme in retroviral replication cycle, and often found as a domain associated with reverse transcriptases. Structure is a mixed alpha+beta fold with three a/b/a layers. Domain PF00692 dUTPase (dUTPase) dUTPase dUTPase hydrolyses dUTP to dUMP and pyrophosphate. Domain
Chains Polymer Molecular Function Biological Process Cellular Component POL POLYPROTEIN catalytic activity, acting on RNA RNA exonuclease activity, producing 5'-phosphomonoesters catalytic activity, acting on a nucleic acid RNA exonuclease activity RNA nuclease activity hydrolase activity exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters nuclease activity hydrolase activity, acting on ester bonds exoribonuclease H activity exonuclease activity catalytic activity cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding DNA binding organic cyclic compound binding nucleic acid binding aspartic-type peptidase activity peptidase activity catalytic activity, acting on a protein aspartic-type endopeptidase activity endopeptidase activity endonuclease activity RNA endonuclease activity, producing 5'-phosphomonoesters RNA-DNA hybrid ribonuclease activity RNA endonuclease activity endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters RNA-directed DNA polymerase activity catalytic activity, acting on DNA DNA polymerase activity transferase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups pyrophosphatase activity nucleoside triphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides dUTP diphosphatase activity hydrolase activity, acting on acid anhydrides transition metal ion binding zinc ion binding Less -
Chains Accession Name Type IPR036397 Ribonuclease H superfamily Homologous Superfamily IPR036157 dUTPase-like superfamily Homologous Superfamily IPR043128 Reverse transcriptase/Diguanylate cyclase domain Homologous Superfamily IPR001995 Peptidase A2A, retrovirus, catalytic Domain IPR021109 Aspartic peptidase domain superfamily Homologous Superfamily IPR001969 Aspartic peptidase, active site Active Site IPR029054 dUTPase-like Domain IPR036862 Integrase, C-terminal domain superfamily, retroviral Homologous Superfamily IPR012337 Ribonuclease H-like superfamily Homologous Superfamily IPR018061 Retropepsins Domain IPR017856 Integrase-like, N-terminal Homologous Superfamily IPR010661 Reverse transcriptase thumb Domain IPR002156 Ribonuclease H domain Domain IPR003308 Integrase, N-terminal zinc-binding domain Domain IPR001584 Integrase, catalytic core Domain IPR008181 Deoxyuridine triphosphate nucleotidohydrolase Family IPR043502 DNA/RNA polymerase superfamily Homologous Superfamily IPR033704 dUTPase, trimeric Domain IPR001037 Integrase, C-terminal, retroviral Domain IPR034170 Retropepsin-like catalytic domain Domain IPR000477 Reverse transcriptase domain Domain IPR010659 Reverse transcriptase connection Domain