1D4U

INTERACTIONS OF HUMAN NUCLEOTIDE EXCISION REPAIR PROTEIN XPA WITH RPA70 AND DNA: CHEMICAL SHIFT MAPPING AND 15N NMR RELAXATION STUDIES

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1d4ua1	All alpha proteins	Putative DNA-binding domain	Putative DNA-binding domain	DNA repair factor XPA DNA- and RPA-binding domain, C-terminal subdomain	DNA repair factor XPA DNA- and RPA-binding domain, C-terminal subdomain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d1d4ua2	Small proteins	Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain	DNA repair factor XPA DNA- and RPA-binding domain, N-terminal subdomain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Glucocorticoid receptor-like (DNA-binding domain)	8039080	3000068	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	beta-hairpin DNA-binding domain-like	8036686	3002139	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF05181	e1d4uA1	A: alpha arrays	X: HTH	H: HTH	T: Putative DNA-binding domain	F: PF05181	ECOD (1.6)
A	PF01286	e1d4uA2	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: PF01286	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.90.530.10	Alpha Beta	Alpha-Beta Complex	Nucleotide Excision Repair Protein XPA (XPA-MBD)	B Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01286	XPA protein N-terminal (XPA_N)	XPA protein N-terminal	-	Domain
A	PF05181	XPA protein C-terminus (XPA_C)	XPA protein C-terminus	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	NUCLEOTIDE EXCISION REPAIR PROTEIN XPA (XPA-MBD)	protein binding binding protein domain specific binding identical protein binding protein homodimerization activity protein dimerization activity DNA binding organic cyclic compound binding damaged DNA binding nucleic acid binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding cation binding protein binding binding protein domain specific binding identical protein binding protein homodimerization activity protein dimerization activity DNA binding organic cyclic compound binding damaged DNA binding nucleic acid binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding cation binding ion binding metal ion binding small molecule binding	response to auditory stimulus response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus cellular response to stimulus primary metabolic process DNA metabolic process nucleotide-excision repair involved in interstrand cross-link repair nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress response to auditory stimulus response to stimulus response to mechanical stimulus response to abiotic stimulus response to external stimulus cellular response to stimulus primary metabolic process DNA metabolic process nucleotide-excision repair involved in interstrand cross-link repair nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response nucleotide-excision repair response to stress metabolic process cellular process interstrand cross-link repair macromolecule metabolic process DNA repair base-excision repair nucleotide-excision repair, DNA damage recognition chromosome organization cellular component organization organelle organization cellular component organization or biogenesis response to light stimulus cellular response to environmental stimulus cellular response to light stimulus cellular response to radiation response to UV UV-damage excision repair response to radiation cellular response to abiotic stimulus cellular response to UV UV protection protein localization localization cellular localization protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to nucleus	intercellular bridge cellular anatomical entity membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle nucleotide-excision repair factor 1 complex intracellular organelle organelle nucleotide-excision repair complex membrane-enclosed lumen intracellular organelle lumen intercellular bridge cellular anatomical entity membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle nucleotide-excision repair factor 1 complex intracellular organelle organelle nucleotide-excision repair complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR022658	XPA, conserved site	Conserved Site
A	IPR009061	Putative DNA-binding domain superfamily	Homologous Superfamily
A	IPR022656	XPA, C-terminal	Domain
A	IPR022652	Zinc finger, XPA-type, conserved site	Conserved Site
A	IPR000465	XPA/RAD14	Family
A	IPR037129	XPA domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P23025	xeroderma pigmentosum skin basal cell carcinoma skin neoplasm xeroderma pigmentosum group A intestinal cancer liver cancer Micronuclei, Chromosome-Defective skin cancer thyroid gland carcinoma Cockayne syndrome hyperthyroidism melanoma ovarian cancer skin pigmented basal cell carcinoma trichothiodystrophy xeroderma pigmentosum skin basal cell carcinoma skin neoplasm xeroderma pigmentosum group A intestinal cancer liver cancer Micronuclei, Chromosome-Defective skin cancer thyroid gland carcinoma Cockayne syndrome hyperthyroidism melanoma ovarian cancer skin pigmented basal cell carcinoma trichothiodystrophy cutaneous melanoma hypothyroidism intestinal neoplasm liver neoplasm pancreatic intraductal papillary-mucinous neoplasm squamous cell carcinoma Hashimoto thyroiditis intellectual disability malignant mesothelioma osteosarcoma progressive supranuclear palsy

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.