Annotations: 1CWV

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1cwva1	All beta proteins	Immunoglobulin-like beta-sandwich	Invasin/intimin cell-adhesion fragments	Invasin/intimin cell-adhesion fragments	Invasin	(Yersinia pseudotuberculosis ) [TaxId: 633 ],	SCOPe (2.08)
A	d1cwva5	Alpha and beta proteins (a+b)	C-type lectin-like	C-type lectin-like	Invasin/intimin cell-adhesion fragment, C-terminal domain	Invasin	(Yersinia pseudotuberculosis ) [TaxId: 633 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Invasin/intimin cell-adhesion fragment C-terminal domain	8024757	4002503	SCOP2 (2022-06-29)
A	SCOP2 Family	Invasin/intimin cell-adhesion fragments	8055356	4007528	SCOP2 (2022-06-29)
A	SCOP2 Family	Invasin/intimin cell-adhesion fragments	8055455	4007528	SCOP2 (2022-06-29)
A	SCOP2 Family	Invasin/intimin cell-adhesion fragments	8055457	4007528	SCOP2 (2022-06-29)
A	SCOP2 Family	Invasin/intimin cell-adhesion fragments	8055459	4007528	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	C-type lectin-like	8037136	3001261	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Invasin/intimin cell-adhesion fragments	8055357	3002046	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Invasin/intimin cell-adhesion fragments	8055456	3002046	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Invasin/intimin cell-adhesion fragments	8055458	3002046	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Invasin/intimin cell-adhesion fragments	8055460	3002046	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Invasin_D3_1	e1cwvA3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Invasin_D3_1	ECOD (1.6)
A	BID_2_like	e1cwvA4	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: BID_2_like	ECOD (1.6)
A	Big_1	e1cwvA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Big_1	ECOD (1.6)
A	Invasin_D3	e1cwvA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Invasin_D3	ECOD (1.6)
A	UNK_F_TYPE	e1cwvA5	A: a+b complex topology	X: C-type lectin-like (From Homology)	H: C-type lectin-like	T: C-type lectin-like	F: UNK_F_TYPE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
A	2.60.40.1080	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
A	3.10.100.10	Alpha Beta	Roll	Mannose-Binding Protein A	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF09134	Invasin, domain 3 (Invasin_D3)	Invasin, domain 3	Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, arranged in a Greek-key topology. It forms part of the extracellular region of the protein, which can be expressed as ...	Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, arranged in a Greek-key topology. It forms part of the extracellular region of the protein, which can be expressed as a soluble protein (Inv497) that binds integrins and promotes subsequent uptake by cells when attached to bacteria [1].	Domain
A	PF07979	Intimin C-type lectin domain (Intimin_C)	Intimin C-type lectin domain	This domain is found at the C-terminus of intimin. Its structure has been solved and shown to have a C-lectin type of structure [1]. Intimin is a bacterial adhesion molecule involved in intimate attachment of enteropathogenic and enterohemorrhagic Es ...	This domain is found at the C-terminus of intimin. Its structure has been solved and shown to have a C-lectin type of structure [1]. Intimin is a bacterial adhesion molecule involved in intimate attachment of enteropathogenic and enterohemorrhagic Escherichia coli to mammalian host cells. Intimin targets the translocated intimin receptor (Tir), which is exported by the bacteria and integrated into the host cell plasma membrane.	Domain
A	PF21764	Invasin, domain 4 (Invasin_D4)	Invasin, domain 4	This domain is found in a group of proteins from Gammaproteobacteria, including Invasin from Yersinia pseudotuberculosis, a protein that allows this enteric bacteria to penetrate cultured mammalian cells by binding several beta-1 chain integrins. Thi ...	This domain is found in a group of proteins from Gammaproteobacteria, including Invasin from Yersinia pseudotuberculosis, a protein that allows this enteric bacteria to penetrate cultured mammalian cells by binding several beta-1 chain integrins. This domain adopts the folding topology of the C1 set of IgSF domains with two additional beta-strands [1].	Domain
A	PF02369	Bacterial Ig-like domain (group 1) (Big_1)	Bacterial Ig-like domain (group 1)	This family consists of bacterial domains with an Ig-like fold. Members of this family are found in bacterial surface proteins such as intimins and invasins involved in pathogenicity.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	INVASIN	-	cell adhesion cellular process	cell surface cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR038177	Inverse autotransporter, beta-domain superfamily	Homologous Superfamily
A	IPR003535	Intimin/invasin bacterial adhesion mediator protein	Family
A	IPR015217	Invasin, domain 3	Domain
A	IPR003344	Big-1 (bacterial Ig-like domain 1) domain	Domain
A	IPR016187	C-type lectin fold	Homologous Superfamily
A	IPR013117	Intimin, C-terminal	Domain
A	IPR048658	Invasin, domain 4	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A	IPR024519	Inverse autotransporter, beta-domain	Domain
A	IPR008964	Invasin/intimin cell-adhesion fragments	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.