1A02

STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth N]	d1a02n1	All beta proteins	Immunoglobulin-like beta-sandwich	E set domains	NF-kappa-B/REL/DORSAL transcription factors, C-terminal domain	T-cell transcription factor NFAT1 (NFATC2)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth N]	d1a02n2	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	p53-like transcription factors	Rel/Dorsal transcription factors, DNA-binding domain	T-cell transcription factor NFAT1 (NFATC), DNA-binding domain	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D [auth F]	d1a02f_	Coiled coil proteins	Parallel coiled-coil	Leucine zipper domain	Leucine zipper domain	C-fos	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E [auth J]	d1a02j_	Coiled coil proteins	Parallel coiled-coil	Leucine zipper domain	Leucine zipper domain	C-jun	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth N]	SCOP2B Superfamily	p53-like transcription factors	8038345	3000758	SCOP2B (2022-06-29)
C [auth N]	SCOP2B Superfamily	E set domains	8054859	3000070	SCOP2B (2022-06-29)
D [auth F]	SCOP2 Family	Leucine zipper domain	8027098	4003836	SCOP2 (2022-06-29)
D [auth F]	SCOP2 Superfamily	Leucine zipper-like	8039477	3001609	SCOP2 (2022-06-29)
E [auth J]	SCOP2B Superfamily	Leucine zipper-like	8032289	3001609	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth N]	RHD_dimer	e1a02N1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: RHD_dimer	ECOD (1.6)
C [auth N]	RHD_DNA_bind	e1a02N2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: RHD_DNA_bind	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth N]	2.60.40.340	Mainly Beta	Sandwich	Immunoglobulin-like	Rel homology domain (RHD), DNA-binding domain	CATH (4.3.0)
C [auth N]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D [auth F]	1.20.5.170	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)
E [auth J]	1.20.5.170	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth N]	PF16179	Rel homology dimerisation domain (RHD_dimer)	Rel homology dimerisation domain	The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (Pfam:PF00554) and a C-terminal dimerisation domain. This is the dimerisation domain [1].	Domain
C [auth N]	PF00554	Rel homology DNA-binding domain (RHD_DNA_bind)	Rel homology DNA-binding domain	Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immu ...	Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See Pfam:PF16179) that functions as a dimerisation domain [1-2].	Domain
D [auth F]	PF00170	bZIP transcription factor (bZIP_1)	bZIP transcription factor	-	Coiled-coil
E [auth J]	PF00170	bZIP transcription factor (bZIP_1)	bZIP transcription factor	-	Coiled-coil

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DNA (5'-D(DTPDTPDGPDGPDAPDAPDAPDAPDTPDTPDTPDGPDTPDTPDTPDCPDAPDTPDAPDG)-3')	-	-	-
B	DNA (5'-D(DAPDAPDCPDTPDAPDTPDGPDAPDAPDAPDCPDAPDAPDAPDTPDTPDTPDTPDCPDC)-3')	-	-	-
C [auth N]	NUCLEAR FACTOR OF ACTIVATED T CELLS	DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein-containing complex binding chromatin binding protein binding 14-3-3 protein binding molecular adaptor activity phosphatase binding enzyme binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity	developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development cellular response to stimulus cellular response to stress response to stimulus DNA damage response developmental process multicellular organism development multicellular organismal process skeletal system development connective tissue development anatomical structure development animal organ development tissue development cartilage development system development cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus calcineurin-NFAT signaling cascade regulation of biological process regulation of cellular process signaling biological regulation intracellular signal transduction cell communication calcium-mediated signaling intracellular signaling cassette signal transduction calcineurin-mediated signaling immune response-regulating cell surface receptor signaling pathway positive regulation of biological process positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response B cell receptor signaling pathway regulation of response to stimulus immune system process regulation of immune response antigen receptor-mediated signaling pathway activation of immune response cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription organic cyclic compound metabolic process nucleic acid biosynthetic process transcription by RNA polymerase II organic cyclic compound biosynthetic process myotube cell development cellular developmental process cell development muscle cell differentiation myotube differentiation muscle structure development muscle cell development cell differentiation striated muscle cell differentiation cell migration cell motility cellular response to inorganic substance cellular response to metal ion response to inorganic substance cellular response to chemical stimulus response to metal ion cellular response to calcium ion response to calcium ion regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of DNA-templated transcription positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of RNA biosynthetic process positive regulation of cellular component organization regulation of cellular component organization regulation of syncytium formation by plasma membrane fusion regulation of developmental process cell-cell fusion cellular component organization positive regulation of developmental process cellular component organization or biogenesis syncytium formation positive regulation of myoblast fusion myoblast fusion regulation of myoblast fusion positive regulation of syncytium formation by plasma membrane fusion syncytium formation by plasma membrane fusion anatomical structure morphogenesis anatomical structure formation involved in morphogenesis smooth muscle cell differentiation negative regulation of biological process regulation of smooth muscle cell differentiation negative regulation of muscle cell differentiation regulation of cell differentiation vascular associated smooth muscle cell differentiation negative regulation of cellular process negative regulation of cell differentiation negative regulation of developmental process negative regulation of vascular associated smooth muscle cell differentiation regulation of vascular associated smooth muscle cell differentiation vasculature development circulatory system development negative regulation of smooth muscle cell differentiation regulation of muscle cell differentiation regulation of transcription by RNA polymerase II positive regulation of cell population proliferation positive regulation of B cell proliferation regulation of leukocyte activation regulation of cell activation lymphocyte activation leukocyte proliferation leukocyte activation positive regulation of lymphocyte activation positive regulation of cell activation regulation of B cell proliferation lymphocyte proliferation regulation of B cell activation positive regulation of leukocyte activation positive regulation of mononuclear cell proliferation regulation of multicellular organismal process regulation of lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation B cell activation cell activation positive regulation of lymphocyte proliferation B cell proliferation positive regulation of B cell activation regulation of cell population proliferation mononuclear cell proliferation positive regulation of leukocyte proliferation regulation of mononuclear cell proliferation positive regulation of multicellular organismal process regulation of lymphocyte activation	RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity transcription factor AP-1 complex intracellular organelle organelle cytoplasm cytosol RNA polymerase II transcription regulator complex membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle cellular anatomical entity transcription factor AP-1 complex intracellular organelle organelle cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle ribonucleoprotein complex
D [auth F]	AP-1 FRAGMENT FOS	SMAD binding protein binding binding R-SMAD binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription factor binding transcription coregulator binding SMAD binding protein binding binding R-SMAD binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription factor binding transcription coregulator binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity core promoter sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein-containing complex binding chromatin binding	response to stimulus response to chemical response to xenobiotic stimulus behavior multicellular organismal process system process learning learning or memory nervous system process feeding behavior cognition associative learning conditioned taste aversion myoblast proliferation response to stimulus response to chemical response to xenobiotic stimulus behavior multicellular organismal process system process learning learning or memory nervous system process feeding behavior cognition associative learning conditioned taste aversion myoblast proliferation cell population proliferation cellular process response to organic substance response to ketone response to lipid response to endogenous stimulus response to progesterone response to oxygen-containing compound response to hormone response to steroid hormone response to organic cyclic compound response to decreased oxygen levels cellular response to stimulus cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus cellular response to stress response to hypoxia response to stress response to oxygen levels response to abiotic stimulus response to light stimulus response to radiation response to toxic substance skeletal muscle cell differentiation developmental process cellular developmental process skeletal muscle tissue development animal organ development tissue development muscle structure development skeletal muscle organ development cell differentiation anatomical structure development muscle tissue development muscle organ development regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription positive regulation of metabolic process regulation of RNA metabolic process regulation of miRNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process cellular biosynthetic process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of miRNA transcription positive regulation of cellular metabolic process positive regulation of miRNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process miRNA transcription organic substance metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process ncRNA metabolic process positive regulation of cellular biosynthetic process regulation of miRNA transcription cellular response to inorganic substance cellular response to metal ion response to inorganic substance response to metal ion cellular response to calcium ion response to calcium ion response to alcohol cellular response to oxygen-containing compound response to phorbol 13-acetate 12-myristate cellular response to alcohol cellular response to phorbol 13-acetate 12-myristate cellular response to lipid cellular response to organic substance cellular response to ketone response to glucocorticoid response to corticosterone response to mineralocorticoid response to corticosteroid response to nutrient levels response to zinc ion starvation cellular response to starvation cellular response to nutrient levels response to starvation cellular response to zinc ion starvation hemopoiesis cell development mononuclear cell differentiation leukocyte differentiation multicellular organism development nervous system development system development response to organonitrogen compound response to organophosphorus response to nitrogen compound response to purine-containing compound response to cAMP signaling integrated stress response signaling intracellular signal transduction cell communication intracellular signaling cassette signal transduction response to cadmium ion cellular response to cadmium ion response to gravity transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cell surface receptor signaling pathway cellular response to transforming growth factor beta stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway multi-multicellular organism process reproductive process female pregnancy multi-organism reproductive process response to activity response to ethanol response to cytokine cellular response to tumor necrosis factor cellular response to cytokine stimulus response to tumor necrosis factor cellular response to nitrogen compound cellular response to prolactin response to prolactin response to peptide hormone cellular response to peptide hormone stimulus cellular response to organonitrogen compound cellular response to hormone stimulus cellular response to oxidative stress cellular response to chemical stress response to reactive oxygen species cellular response to reactive oxygen species response to oxidative stress SMAD protein signal transduction response to immobilization stress response to insulin cellular response to parathyroid hormone stimulus response to parathyroid hormone myeloid leukocyte differentiation myeloid cell differentiation osteoclast differentiation defense response inflammatory response cellular response to epidermal growth factor stimulus response to epidermal growth factor biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to lipopolysaccharide response to biotic stimulus response to bacterium response to external biotic stimulus response to molecule of bacterial origin muscle cell proliferation skeletal muscle cell proliferation striated muscle cell proliferation response to mechanical stimulus response to muscle stretch regulation of leukocyte differentiation regulation of developmental process regulation of cell differentiation positive regulation of osteoclast differentiation regulation of cell development positive regulation of developmental process regulation of osteoclast differentiation positive regulation of cell differentiation positive regulation of hemopoiesis regulation of immune system process regulation of multicellular organismal process positive regulation of immune system process regulation of multicellular organismal development regulation of myeloid cell differentiation positive regulation of cell development regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation immune system process positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of multicellular organismal process positive regulation of leukocyte differentiation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle RNA polymerase II transcription regulator complex membrane-bounded organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol intracellular organelle protein-containing complex protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle RNA polymerase II transcription regulator complex membrane-bounded organelle nucleus nuclear protein-containing complex transcription regulator complex intracellular membrane-bounded organelle transcription factor AP-1 complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen endoplasmic reticulum endomembrane system
E [auth J]	AP-1 FRAGMENT JUN	SMAD binding protein binding binding R-SMAD binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding cAMP response element binding organic cyclic compound binding SMAD binding protein binding binding R-SMAD binding DNA binding sequence-specific DNA binding double-stranded DNA binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding cAMP response element binding organic cyclic compound binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding transcription factor binding general transcription initiation factor binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding RNA binding	regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process cellular process apoptotic process programmed cell death positive regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process cellular process apoptotic process programmed cell death positive regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription positive regulation of metabolic process regulation of RNA metabolic process regulation of miRNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process cellular biosynthetic process positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of cellular metabolic process positive regulation of miRNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process miRNA transcription organic substance metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process ncRNA metabolic process positive regulation of cellular biosynthetic process regulation of miRNA transcription viral gene expression biological process involved in interspecies interaction between organisms modulation by host of symbiont process viral process biological process involved in interaction with symbiont viral transcription positive regulation by host of viral transcription biological process involved in symbiotic interaction cellular response to stimulus response to stimulus signaling integrated stress response signaling intracellular signal transduction cell communication cellular response to stress response to stress intracellular signaling cassette signal transduction negative regulation of biological process negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process cellular response to inorganic substance cellular response to metal ion response to cadmium ion response to inorganic substance cellular response to chemical stimulus response to metal ion response to chemical cellular response to cadmium ion positive regulation of transcription by RNA polymerase II cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cell surface receptor signaling pathway cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway response to endoplasmic reticulum stress negative regulation by host of viral transcription latent virus replication viral latency release from viral latency regulation of vascular associated smooth muscle cell proliferation cell population proliferation positive regulation of vascular associated smooth muscle cell proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation vascular associated smooth muscle cell proliferation cellular response to oxidative stress response to oxygen-containing compound cellular response to chemical stress cellular response to oxygen-containing compound response to reactive oxygen species cellular response to reactive oxygen species response to oxidative stress SMAD protein signal transduction regulation of DNA-templated transcription initiation positive regulation of DNA-templated transcription initiation DNA-templated transcription initiation regulation of molecular function regulation of DNA binding regulation of binding negative regulation of binding negative regulation of molecular function negative regulation of DNA binding cell cycle regulation of cell cycle	protein-containing complex transcription regulator complex intracellular organelle intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen protein-containing complex transcription regulator complex intracellular organelle intracellular anatomical structure protein-DNA complex organelle intracellular non-membrane-bounded organelle chromatin chromosome cellular anatomical entity non-membrane-bounded organelle membrane-bounded organelle nucleus membrane-enclosed lumen nuclear chromosome intracellular membrane-bounded organelle intracellular organelle lumen organelle lumen nuclear lumen RNA polymerase II transcription regulator complex nuclear protein-containing complex transcription factor AP-1 complex nucleoplasm euchromatin

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth N]	IPR037059	Rel homology domain (RHD), DNA-binding domain superfamily	Homologous Superfamily
C [auth N]	IPR002909	IPT domain	Domain
C [auth N]	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily
C [auth N]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
C [auth N]	IPR011539	Rel homology domain, DNA-binding domain	Domain
C [auth N]	IPR008366	Nuclear factor of activated T cells (NFAT)	Family
C [auth N]	IPR032397	Rel homology dimerisation domain	Domain
C [auth N]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
D [auth F]	IPR004827	Basic-leucine zipper domain	Domain
D [auth F]	IPR000837	AP-1 transcription factor	Family
D [auth F]	IPR046347	Basic-leucine zipper domain superfamily	Homologous Superfamily
E [auth J]	IPR002112	Transcription factor Jun	Family
E [auth J]	IPR004827	Basic-leucine zipper domain	Domain
E [auth J]	IPR008917	Transcription factor, Skn-1-like, DNA-binding domain superfamily	Homologous Superfamily
E [auth J]	IPR005643	Jun-like transcription factor	Domain
E [auth J]	IPR046347	Basic-leucine zipper domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth N]	Pharos: Q13469	nervous system disorder pulmonary hypertension allergic rhinitis malignant ependymoma non-small cell lung carcinoma subependymal giant cell astrocytoma breast cancer medulloblastoma osteosarcoma type 2 diabetes mellitus interstitial cystitis ulcerative colitis
D [auth F]	Pharos: P01100	hepatocellular carcinoma status epilepticus breast carcinoma hypertensive disorder amyotrophic lateral sclerosis type 1 middle cerebral artery infarction epilepsy breast cancer visual epilepsy cancer Heat Stroke cocaine abuse nervous system disorder extrahepatic cholestasis trigeminal neuralgia hepatocellular carcinoma status epilepticus breast carcinoma hypertensive disorder amyotrophic lateral sclerosis type 1 middle cerebral artery infarction epilepsy breast cancer visual epilepsy cancer Heat Stroke cocaine abuse nervous system disorder extrahepatic cholestasis trigeminal neuralgia cocaine dependence amphetamine abuse McCune-Albright syndrome anxiety disorder substance withdrawal syndrome juvenile idiopathic arthritis endometriosis toxic encephalopathy non-small cell lung carcinoma facioscapulohumeral muscular dystrophy lung adenocarcinoma osteitis fibrosa gastric cancer lung carcinoma breast fibroadenoma periodontitis major depressive disorder psoriasis malignant mesothelioma rheumatoid arthritis adrenal cortex carcinoma congenital generalized lipodystrophy Crohn disease inflammatory bowel disease Down syndrome astrocytic tumor nephrosclerosis limb-girdle muscular dystrophy transitional cell carcinoma ulcerative colitis lung benign neoplasm gastric carcinoma glioblastoma malignant colon neoplasm pterygium acute myeloid leukemia medulloblastoma digestive system disease lipoatrophic diabetes B-cell chronic lymphocytic leukemia brain injury lung cancer ovarian cancer lymphoplasmacytic lymphoma pituitary cancer malignant ependymoma adenoma Sjogren syndrome ischemia reperfusion injury
E [auth J]	Pharos: P05412	osteosarcoma angiosarcoma status epilepticus malignant colon neoplasm breast carcinoma peripheral nervous system disease gastric cancer hypertensive disorder breast cancer liver cancer peripheral neuropathy extrahepatic cholestasis hepatocellular carcinoma brain ischemia cancer osteosarcoma angiosarcoma status epilepticus malignant colon neoplasm breast carcinoma peripheral nervous system disease gastric cancer hypertensive disorder breast cancer liver cancer peripheral neuropathy extrahepatic cholestasis hepatocellular carcinoma brain ischemia cancer Heat Stroke juvenile idiopathic arthritis liver disease lung cancer colonic neoplasm pituitary cancer exocrine pancreatic carcinoma acute myeloid leukemia schizophrenia glioblastoma malignant pancreatic neoplasm hematologic disease medulloblastoma atypical teratoid rhabdoid tumor type 2 diabetes mellitus benign colon neoplasm Minamata disease brain injury ischemia reperfusion injury nephrosclerosis non-small cell lung carcinoma breast fibroadenoma liver neoplasm ovarian cancer lung carcinoma lymphatic system disease psoriasis rheumatoid arthritis gastric carcinoma adenoma silicosis arthritic joint disease autoimmune disease inborn carbohydrate metabolic disorder intestinal polyp myopathy neurodegenerative disease obesity disorder lung benign neoplasm pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia cerebrovascular disorder lung disease lymphoplasmacytic lymphoma pterygium fetal methylmercury syndrome malignant mesothelioma sarcoma gastric neoplasm amyotrophic lateral sclerosis astrocytic tumor tuberculosis hereditary diffuse gastric adenocarcinoma B-cell chronic lymphocytic leukemia breast disease large cell medulloblastoma

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.