16VP

CONSERVED CORE OF THE HERPES SIMPLEX VIRUS TRANSCRIPTIONAL REGULATORY PROTEIN VP16

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d16vpa_	Alpha and beta proteins (a+b)	Conserved core of transcriptional regulatory protein vp16	Conserved core of transcriptional regulatory protein vp16	Conserved core of transcriptional regulatory protein vp16	Conserved core of transcriptional regulatory protein vp16	Herpes simplex virus type 1 (Human alphaherpesvirus 1 ) [TaxId: 10298 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Conserved core of transcriptional regulatory protein vp16	8024899	4002615	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Conserved core of transcriptional regulatory protein vp16	8037278	3001486	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02232	e16vpA1	A: a+b complex topology	X: Conserved core of transcriptional regulatory protein vp16 (From Topology)	H: Conserved core of transcriptional regulatory protein vp16 (From Topology)	T: Conserved core of transcriptional regulatory protein vp16	F: PF02232	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.1290.10	Mainly Alpha	Orthogonal Bundle	Conserved core of transcriptional regulatory protein vp16	Alpha trans-inducing (Alpha-TIF)	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	PROTEIN (VP16, VMW65, ATIF)	DNA binding binding organic cyclic compound binding nucleic acid binding transcription factor binding protein binding DNA-binding transcription factor binding sequence-specific DNA binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding DNA binding binding organic cyclic compound binding nucleic acid binding transcription factor binding protein binding DNA-binding transcription factor binding sequence-specific DNA binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding molecular function activator activity molecular function regulator activity transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity core promoter sequence-specific DNA binding structural constituent of virion structural molecule activity DNA-binding transcription factor activity	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis viral gene expression regulation of biological process regulation of viral process regulation of viral transcription viral process biological regulation viral transcription cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis viral gene expression regulation of biological process regulation of viral process regulation of viral transcription viral process biological regulation viral transcription regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process DNA-templated viral transcription biological process involved in interspecies interaction between organisms biological process involved in interaction with host biological process involved in symbiotic interaction transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II	virion component viral tegument protein-containing complex transcription regulator complex host intracellular membrane-bounded organelle host cellular component host intracellular part cellular anatomical entity nuclear viral factory host cell nucleus host intracellular organelle viral factory host cell part replication compartment virion component viral tegument protein-containing complex transcription regulator complex host intracellular membrane-bounded organelle host cellular component host intracellular part cellular anatomical entity nuclear viral factory host cell nucleus host intracellular organelle viral factory host cell part replication compartment host intracellular region host cell cytoplasm host cell perinuclear region of cytoplasm host cell cytoplasm part host cell cytoplasmic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR021051	Herpes simplex virus, Tegument protein VP16, C-terminal	Domain
A	IPR036538	Alpha trans-inducing (Alpha-TIF) superfamily	Homologous Superfamily
A	IPR003174	Alpha trans-inducing protein (Alpha-TIF)	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.